Two faces of BRD4 Mitotic bookmark and transcriptional lynchpin

被引：70

作者：

Devaiah, Ballachanda N. ^{[1
]}

Singer, Dinah S. ^{[1
]}

机构：

[1] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA

来源：

TRANSCRIPTION-AUSTIN | 2013年 / 4卷 / 01期

关键词：

BRD4; BET protein; Atypical kinase; RNA Polymerase II; CTD kinase; P-TEFb;

D O I：

10.4161/trns.22542

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The bromodomain protein BRD4 links cell cycle and transcription, bookmarking active genes during mitosis and serving as a scaffold for transcription factors. Our recent discovery that BRD4 is a RNA Polymerase II CTD kinase identifies a novel transcriptional function. Here we discuss our model in the context of current knowledge.

引用

页码：13 / 17

页数：5

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