Two faces of BRD4 Mitotic bookmark and transcriptional lynchpin

被引：69
作者：
Devaiah, Ballachanda N. [1 ]
Singer, Dinah S. [1 ]
机构：
[1] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA
来源：
TRANSCRIPTION-AUSTIN | 2013年 / 4卷 / 01期
关键词：
BRD4; BET protein; Atypical kinase; RNA Polymerase II; CTD kinase; P-TEFb;
D O I：
10.4161/trns.22542
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The bromodomain protein BRD4 links cell cycle and transcription, bookmarking active genes during mitosis and serving as a scaffold for transcription factors. Our recent discovery that BRD4 is a RNA Polymerase II CTD kinase identifies a novel transcriptional function. Here we discuss our model in the context of current knowledge.
引用
收藏
页码：13 / 17
页数：5
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