GLYCOSYLIMIDATES .46. TOTAL SYNTHESIS OF A HEXAOSYL CERAMIDE GLYCOLIPID ACTING AS A RECEPTOR FOR MACROPHAGE-MIGRATION INHIBITION-FACTOR

被引：33

作者：

ZIMMERMANN, P ^{[1
]}

GREILICH, U ^{[1
]}

SCHMIDT, RR ^{[1
]}

机构：

[1] UNIV CONSTANCE,FAK CHEM,W-7750 CONSTANCE,GERMANY

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(00)98802-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of the glycosphingolipid1 constituting a macrophage receptor for MIF is described. It is based on trichloroacetimidate glycosyl donors and on the azidosphingosine glycosylation method. Regioselective O-glycosylation of a partially O-protected acceptor and direct transformation of the sphingosine azido group into a fatty acyl amido function were successfully applied in the execution of the synthesis. © 1990 Pergamon Press plc.

引用

页码：1849 / 1852

页数：4

共 26 条

[1]

BOMMER R, 1989, LIEBIGS ANN CHEM, P1107

[2] GANGLIOSIDES BLOCK THE INHIBITION OF MACROPHAGE FC-DEPENDENT PHAGOCYTOSIS BY LIPOPOLYSACCHARIDE [J].