EFFECT OF CYPROTERONE-ACETATE ON THE STRUCTURE OF THE ADRENAL-CORTEX

被引：5

作者：

MIGALLY, N ^{[1
]}

机构：

[1] MED COLL WISCONSIN,DEPT ANAT,MILWAUKEE,WI 53233

来源：

ARCHIVES OF ANDROLOGY | 1979年 / 2卷 / 02期

关键词：

Adrenal cortex; Cyproterone acetate; Electron microscopy;

D O I：

10.3109/01485017908987301

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

Adult male C57 B176J mice injected with 0.08 mg/g of cyproterone acetate showed an increase in cellular lipid content in the zona fasciculata and zona reticularis of the adrenal cortex. In the perimedullary region, densely staining cells aggregated to form scattered nodules. At the ultra-structural level, in the zona glomerulosa and zona fasciculata the number and size of lipid droplets increased. An apparent decrease in mitochondrial number and size and a noticeable diminution in the amount of smooth endoplasmic reticulum were also noted in the zona fasciculata. It is suggested that cyproterone acetate may have blocked steroid synthesis and increased adrenal cholesterol deposits. © 1979 Informa UK Ltd.

引用

页码：109 / 115

页数：7

共 18 条

[1] LOCALIZATION OF A STEROID 11 BETA-HYDROXYLASE IN INNER MEMBRANE SUBFRACTION OF RAT ADRENAL MITOCHONDRIA [J].