ELEVATED LEVELS OF SOLUBLE ICAM-1 IN SERA FROM PATIENTS WITH BRONCHIAL-ASTHMA

被引：45

作者：

HASHIMOTO, S ^{[1
]}

IMAI, K ^{[1
]}

KOBAYASHI, T ^{[1
]}

AMEMIYA, E ^{[1
]}

TAKAHASHI, Y ^{[1
]}

TOMITA, Y ^{[1
]}

IWATA, T ^{[1
]}

SUGURO, H ^{[1
]}

YAMAGUCHI, M ^{[1
]}

YACHI, A ^{[1
]}

HORIE, T ^{[1
]}

机构：

[1] SAPPORO MED SCH,DEPT INTERNAL MED,SAPPORO,JAPAN

来源：

ALLERGY | 1993年 / 48卷 / 05期

关键词：

BRONCHIAL ASTHMA; INTERCELLULAR ADHESION MOLECULE-1;

D O I：

10.1111/j.1398-9995.1993.tb02408.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

We measured the levels of soluble intercellular adhesion molecule-1 (sICAM-1) in sera from patients with bronchial asthma. sICAM-1 levels in sera from atopic asthmatic patients in stable conditions were higher than in normal control subjects. Furthermore, the sICAM-1 levels in sera obtained during bronchial asthma attacks were higher than those in sera obtained in stable conditions. These results suggest that higher levels of sICAM-1 in sera reflect the upregulation of ICAM-1 expression in allergic inflammation.

引用

页码：370 / 372

页数：3

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