DIVERSITY IN FUNCTION AND REGULATION OF MAP KINASE PATHWAYS

被引：451
作者：
BLUMER, KJ [1 ]
JOHNSON, GL [1 ]
机构：
[1] NATL JEWISH CTR IMMUNOL & RESP MED,DIV BASIC SCI,DENVER,CO 80206
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 06期
关键词：
D O I：
10.1016/0968-0004(94)90147-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eukaryotic cells from yeast to humans use sequential protein kinase reactions to regulate complex cellular functions. Equivalent protein kinases in different pathways have significant sequence homologies; however, little crossover in phosphorylation of substrates between pathways normally occurs. Assembly of kinase complexes and discrimination of substrates provide the selectivity of sequential protein kinase pathways to regulate such diverse cellular functions as osmoregulation, cell-wall biosynthesis, growth and differentiation.
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页码：236 / 240
页数：5
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