THE PNEUMOTOXICANT PARAQUAT POTENTIATES IL-1 AND TNF PRODUCTION BY HUMAN MONONUCLEAR-CELLS

被引：11
作者：
ERROI, A
BIANCHI, M
GHEZZI, P
机构：
[1] Istituto di Ricerche Farmacologiche 'Mario Negri', Milan, 20157
来源：
AGENTS AND ACTIONS | 1992年 / 36卷 / 1-2期
关键词：
D O I：
10.1007/BF01991230
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Interleukin 1 (IL-1) and tumor necrosis factor (TNF) have been implicated in the pathogenesis of bleomycin- and silica-induced lung damage. We have studied the effect of paraquat (PQ), a well-known pneumotoxicant, on IL-1 and TNF production by human peripheral blood mononuclear cells from different healthy donors stimulated with endotoxin. PQ (100-mu-M) potentiated IL-1 production (2-40 fold) and TNF production (2-18 fold). It is, therefore, possible that IL-1 and TNF are also involved in the pneumotoxic action of PQ.
引用
收藏
页码：66 / 69
页数：4
相关论文
共 50 条
[41]   SPECIFIC RADIOIMMUNOASSAYS FOR HUMAN INTERLEUKIN-1-ALPHA AND INTERLEUKIN-1-BETA - THE INFLUENCE OF VARIOUS CULTURE CONDITIONS ON THE PRODUCTION OF IMMUNOREACTIVE IL-1 FROM HUMAN MONONUCLEAR-CELLS [J].
LONNEMANN, G ;
ENDRES, S ;
CANNON, JG ;
VANDERMEER, JWM ;
IKEJIMA, T ;
DINARELLO, CA .
JOURNAL OF LEUKOCYTE BIOLOGY, 1987, 42 (05) :603-603
[42]   EFFECT OF VITAMIN-E SUPPLEMENTATION ON INVITRO IGM AND IL-1 PRODUCTION BY BOVINE PERIPHERAL-BLOOD MONONUCLEAR-CELLS [J].
STABEL, JR ;
STEVENS, MG ;
NONNECKE, BJ ;
REINHARDT, TA .
FASEB JOURNAL, 1991, 5 (04) :A566-A566
[43]   IL-2 STIMULATES THE PRODUCTION OF IL-1-ALPHA AND IL-1-BETA BY HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS [J].
NUMEROF, RP ;
ARONSON, FR ;
MIER, JW .
JOURNAL OF IMMUNOLOGY, 1988, 141 (12) :4250-4257
[44]   THE EFFECT OF SOMATOSTATIN ON THE PRODUCTION OF HUMAN INTERFERONS BY MONONUCLEAR-CELLS [J].
YOUSEFI, S ;
GHAZINOURI, A ;
VAZIRI, N ;
TILLES, J ;
CARANDANG, G ;
CESARIO, T .
PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1990, 194 (02) :114-118
[45]   THE EFFECT OF SOMATOSTATIN ON THE PRODUCTION OF HUMAN INTERFERONS BY MONONUCLEAR-CELLS [J].
YOUSEFI, S ;
GHAZINOURI, A ;
VAZIRI, N ;
CARANDANG, G ;
CESARIO, T .
CLINICAL RESEARCH, 1989, 37 (02) :A445-A445
[46]   PROSTAGLANDIN AND THROMBOXANE PRODUCTION BY POPULATIONS OF HUMAN MONONUCLEAR-CELLS [J].
KENNEDY, MS ;
GOLDYNE, M ;
STOBO, JD .
CLINICAL RESEARCH, 1980, 28 (01) :A77-A77
[47]   INDUCTION OF METALLOTHIONEIN PRODUCTION BY ZINC IN HUMAN MONONUCLEAR-CELLS [J].
MESNA, OJ ;
STEFFENSEN, IL ;
MELHUUS, A ;
HJERTHOLM, H ;
HEIER, HE ;
ANDERSEN, RA .
GENERAL PHARMACOLOGY, 1990, 21 (06) :909-917
[48]   THE EFFECT OF HORMONES ON THE PRODUCTION OF INTERFERONS BY HUMAN MONONUCLEAR-CELLS [J].
KARAMLO, K ;
YOUSEFI, S ;
VAZIRI, N ;
CARANDANG, G ;
CESARIO, T .
CLINICAL RESEARCH, 1992, 40 (01) :A53-A53
[49]   INTERLEUKIN-1 (IL-1) RECEPTOR BLOCKADE REDUCES ENDOTOXIN AND BORRELIA BURGDORFERI-STIMULATED IL-8 SYNTHESIS IN HUMAN MONONUCLEAR-CELLS [J].
PORAT, R ;
POUTSIAKA, DD ;
MILLER, LC ;
GRANOWITZ, EV ;
DINARELLO, CA .
FASEB JOURNAL, 1992, 6 (07) :2482-2486
[50]   Differential regulation of human dermal endothelial cells by IL-1β and TNFα [J].
Moeller-Olsen, C. ;
Du Mez, E. ;
Kho, D. ;
Johnson, R. ;
Feisst, V. ;
O'Carroll, S. ;
Locke, M. ;
Angel, C. E. ;
Graham, E. S. .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 :1263-1264
12345