THE PNEUMOTOXICANT PARAQUAT POTENTIATES IL-1 AND TNF PRODUCTION BY HUMAN MONONUCLEAR-CELLS

被引：11
作者：
ERROI, A
BIANCHI, M
GHEZZI, P
机构：
[1] Istituto di Ricerche Farmacologiche 'Mario Negri', Milan, 20157
来源：
AGENTS AND ACTIONS | 1992年 / 36卷 / 1-2期
关键词：
D O I：
10.1007/BF01991230
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Interleukin 1 (IL-1) and tumor necrosis factor (TNF) have been implicated in the pathogenesis of bleomycin- and silica-induced lung damage. We have studied the effect of paraquat (PQ), a well-known pneumotoxicant, on IL-1 and TNF production by human peripheral blood mononuclear cells from different healthy donors stimulated with endotoxin. PQ (100-mu-M) potentiated IL-1 production (2-40 fold) and TNF production (2-18 fold). It is, therefore, possible that IL-1 and TNF are also involved in the pneumotoxic action of PQ.
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页码：66 / 69
页数：4
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