REFORMATSKY REACTION OF ETHYL 4-CHLORO-4,4-DIFLUOROCROTONATE - PREPARATION OF ALPHA-SUBSTITUTED 4,4-DIFLUORO-3-BUTENOATES

被引：0

作者：

TSUKAMOTO, T ^{[1
]}

KITAZUME, T ^{[1
]}

机构：

[1] TOKYO INST TECHNOL,DEPT BIOENGN,MIDORI KU,YOKOHAMA,KANAGAWA 227,JAPAN

来源：

SYNLETT | 1992年 / 12期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reformatsky reagent derived from ethyl 4-chloro-4,4-difluorocrotonate was found to react with carbonyl compounds in the a-mode by using Zn-Cu couple to afford alpha-substituted 4,4-difluoro-3-butenoates.

引用

页码：977 / 979

页数：3

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[21] The unusual reaction of 1,1′-dialkyl-3,3′-di(2-quinolyl)-1,1′,4,4′-tetrahydro-4,4′-biquinolines with ethyl chloroformate [J].

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[25] Reaction of 4-chloro- and 4-bromobenzene-1,3-diols with 1-alkyl-3-(4,4-diethoxybutyl)ureas in the presence of trifluoroacetic acid [J].

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[26] Reaction of 4-chloro- and 4-bromobenzene-1,3-diols with 1-alkyl-3-(4,4-diethoxybutyl)ureas in the presence of trifluoroacetic acid [J].

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[27] ACTIVE HETEROMETHYLENE COMPOUNDS .3. SYNTHESIS OF 4,4-DIFLUORO-2-AZETIDINONES FROM ALPHA-HALOACETAMIDES AND FREON-22 [J].

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OHASHI, Y ;

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