POTENTIATION OF BEHAVIORAL-EFFECTS OF A CALCIUM-CHANNEL ANTAGONIST, NIFEDIPINE, BY IPSAPIRONE

被引：0
|
作者：
TAZI, A
FARH, M
MOUMNI, M
HAKKOU, F
机构：
来源：
BEHAVIOURAL PHARMACOLOGY | 1992年 / 3卷 / 03期
关键词：
FORCED SWIM TEST; IPSAPIRONE; NIFEDIPINE; NOVEL ENVIRONMENT; WATER INTAKE;
D O I：
暂无
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The synergistic effect between the 5-HT1A agonist ipsapirone and the calcium channel antagonist, nifedipine, was studied in animal models of anxiety and depression. Ipsapirone (1.5, 3.0 and 6.0 mg/kg) dose dependently potentiated the behavioural effects of a small and ineffective dose of nifedipine (2.0 mg/kg) in the two experimental paradigms. This potentiation was revealed by a decrease in immobilisation time in the forced swim test (antidepressant-like effect) and by an increase in water-consumption in a novel environment (anxiolytic-like effect). The data obtained are discussed in terms of the neurochemical effects of ipsapirone on the serotonergic system, and the possible interaction between nifedipine and this system.
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页码：269 / 273
页数：5
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