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[1]
YAMAHARA J, 1978, J PHARM SOC JAPAN, V98, P1446
ANTICHOLINERGIC ACTION OF SWERTIA-JAPONICA AND AN ACTIVE CONSTITUENT
被引：47
作者：
YAMAHARA, J
KOBAYASHI, M
MATSUDA, H
AOKI, S
机构：
[1] Kyoto Pharmaceutical University, Yamashina-ku, Kyoto, 607, Misasagi
关键词：
SWERTIA-JAPONICA;
ANTICHOLINERGIC ACTION;
PROXIMAL COLON;
SWERTIAMARIN;
D O I：
10.1016/0378-8741(91)90157-9
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The anticholinergic action of Swertia japonica, used in Japan as a bitter stomachic, was examined using in vivo experiments in rats in order to substantiate the presence or absence of antispasmodic properties. The methanol extract of Swertia japonica was found to be an effective anticholinergic given orally. Fractionation and purification of the methanol extract through column chromatography revealed that swertiamarin, found in the methanol extract in amounts of about 30%, was an active constituent with an anticholinergic action.
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页码：31 / 35
页数：5
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