POLY(L-LACTIDE) - A LONG-TERM DEGRADATION STUDY IN-VIVO .1. BIOLOGICAL RESULTS

被引：112

作者：

PISTNER, H ^{[1
]}

GUTWALD, R ^{[1
]}

ORDUNG, R ^{[1
]}

REUTHER, J ^{[1
]}

MUHLING, J ^{[1
]}

机构：

[1] UNIV HEIDELBERG,MUND KIEFER & GESICHTSCHIRURG PLAST OPERAT KLIN & POLIKLIN,W-6900 HEIDELBERG,GERMANY

来源：

BIOMATERIALS | 1993年 / 14卷 / 09期

关键词：

POLYLACTIDES; BIODEGRADATION; BIOCOMPATIBILITY; TUMORIGENESIS;

D O I：

10.1016/0142-9612(93)90066-B

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Three poly(L-lactides) with different molecular weights were synthesized. Small blocks (3 X 3 X 2 mm) and rods (25 X 3 X 2 mm) were produced either by injection moulding (amorphous parts, M(vis) 200 000 and 120 000, respectively) or machined out of a solid as-polymerized polylactide block (crystalline parts, M(vis) 429 000) and implanted into the dorsal muscle of rats. After 1 to 116 wk the rats were killed and the implants were recovered. Histological preparation was carried out using the cutting-grinding technique. All three polylactides had incorporated well, forming a collagenous fibrous layer. Crystalline block polylactide remained stable in form and structure over the whole observation period. Amorphous injection-moulded specimens developed a rough surface within weeks, then deep resorptive lacunae after ca. 1 yr and became totally degraded (M(vis) 120 000) or nearly totally degraded (M(vis) 200 000) after 2 yr. This velocity of biodegradation seems to meet the requirements for an absorbable material for osteosynthesis. Long-term implantation into rodents brings the problem of foreign-body tumorigenesis independent of the chemical nature of implants (the Oppenheimer effect). Observations in this study and in the literature are discussed.

引用

页码：671 / 677

页数：7