EFFECTS OF SOMATOSTATIN ON POTASSIUM CURRENTS IN BULLFROG SYMPATHETIC-GANGLION NEURONS - POSSIBLE ROLE OF RECEPTOR SUBTYPES

被引：7
|
作者：
KURENNY, DE [1 ]
CHEN, H [1 ]
SMITH, PA [1 ]
机构：
[1] UNIV ALBERTA,DEPT PHARMACOL,9-75 MED SCI BLDG,EDMONTON T6G 2H7,ALBERTA,CANADA
来源：
NEUROSCIENCE LETTERS | 1992年 / 139卷 / 02期
关键词：
M-CURRENT; INWARD RECTIFICATION; PEPTIDE; AUTONOMIC GANGLION; MUSCARINE; K+ CURRENT; AMPHIBIAN; G-PROTEIN;
D O I：
10.1016/0304-3940(92)90559-P
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of whole somatostatin (wSS; somatostatin-28) and cyclic somatostatin (cSS; somatostatin-14) were examined on patch-clamped bullfrog sympathetic ganglion neurones. In the C-cells, where muscarine produces hyperpolarization, wSS was also inhibitory and activated an inwardly-rectifying K+ current; cSS was ineffective. By contrast, in the B-cells, where muscarine produces excitatory effects, cSS was also excitatory and was more effective than wSS in suppressing a voltage-dependent, non-inactivating K+-current (I(M)). These results are consistent with the idea that excitatory and inhibitory effects of somatostatin-derived peptides may be mediated via different receptor subtypes.
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页码：227 / 230
页数：4
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