MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF THE MOUSE KALLIKREIN-BINDING PROTEIN GENE

被引：18
作者：
CHAI, KX [1 ]
CHAO, J [1 ]
CHAO, L [1 ]
机构：
[1] MED UNIV S CAROLINA,DEPT BIOCHEM & MOLEC BIOL,171 ASHLEY AVE,CHARLESTON,SC 29425
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1129卷 / 01期
关键词：
KALLIKREIN-BINDING PROTEIN GENE; CLONING; SEQUENCE ANALYSIS; (MOUSE);
D O I：
10.1016/0167-4781(91)90227-D
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A genomic clone (MKBP-10) encoding the mouse kallikrein-binding protein (MKBP) was isolated from a mouse genomic DNA library by screening with a rat kallikrein-binding protein (RKBP) cDNA probe. The total sequenced region of the MKBP gene spans 8615 base pairs. The exon and intron locations of the RKBP gene were identified by similarity with the RKBP gene. The MKBP gene encodes a prepeptide of 417 amino acid residues which exhibits 71% homology with RKBP. A TATA box sequence was located in the 5' flanking region of the MKBP gene by similarity with the consensus sequence TATAAAA.
引用
收藏
页码：127 / 130
页数：4
相关论文
共 15 条
  • [1] OVALBUMIN GENE-SEQUENCE OF PUTATIVE CONTROL REGIONS
    BENOIST, C
    OHARE, K
    BREATHNACH, R
    CHAMBON, P
    [J]. NUCLEIC ACIDS RESEARCH, 1980, 8 (01) : 127 - 142
  • [2] Carrell R.W, 1986, PROTEINASE INHIBITOR, P403
  • [3] CHAI KX, 1991, J BIOL CHEM, V266, P16029
  • [4] CHAO J, 1990, J BIOL CHEM, V265, P16394
  • [5] A MAJOR DIFFERENCE OF KALLIKREIN-BINDING PROTEIN IN SPONTANEOUSLY HYPERTENSIVE VERSUS NORMOTENSIVE RATS
    CHAO, J
    CHAO, L
    [J]. JOURNAL OF HYPERTENSION, 1988, 6 (07) : 551 - 557
  • [6] IDENTIFICATION OF A NEW TISSUE-KALLIKREIN-BINDING PROTEIN
    CHAO, J
    TILLMAN, DM
    WANG, M
    MARGOLIUS, HS
    CHAO, L
    [J]. BIOCHEMICAL JOURNAL, 1986, 239 (02) : 325 - 331
  • [7] DIFFERENTIAL INTERACTIONS OF HUMAN KALLIKREIN-BINDING PROTEIN AND ALPHA-1-ANTITRYPSIN WITH HUMAN TISSUE KALLIKREIN
    CHEN, LM
    CHAO, L
    MAYFIELD, RK
    CHAO, J
    [J]. BIOCHEMICAL JOURNAL, 1990, 267 (01) : 79 - 84
  • [8] MOLECULAR-BIOLOGY OF TISSUE KALLIKREIN
    MACDONALD, RJ
    MARGOLIUS, HS
    ERDOS, EG
    [J]. BIOCHEMICAL JOURNAL, 1988, 253 (02) : 313 - 321
  • [9] Marshall R D, 1974, Biochem Soc Symp, P17
  • [10] MESSING J, 1983, METHOD ENZYMOL, V101, P20
12