REGRESSION OF LEFT-VENTRICULAR HYPERTROPHY IN HYPERTENSIVES DURING LONG-TERM TREATMENT WITH ANTIHYPERTENSIVE AGENTS

被引:10
作者
FRANZ, IW [1 ]
TONNESMANN, U [1 ]
BEHR, U [1 ]
KETELHUT, R [1 ]
机构
[1] INST LEISTUNGSMED BERLIN,W-1000 BERLIN 33,GERMANY
关键词
D O I
10.1055/s-2008-1065053
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effect of long-term therapy of hypertension with antihypertensive drugs was investigated in 117 previously untreated patients (15 women, 102 men; mean age 46.4 ± 9 years) with echocardiographically proven left-ventricular hypertrophy. 22 patients (group 1) received 100 mg/d Gallopamil, 25 (group 2) received 200 mg/d Metoprolol, 35 daily received both 50 mg Atenolol and 20 mg Nifedipine (group 3), 14 received daily 200 mg Acebutolol plus 20 mg Nifedipine (group 4), and 21 (group 5) 50 mg Atenolol plus 10 mg Enalapril daily. The treatment period lasted a mean of 38 (36.2-42.3) months. Left-ventricular muscle mass index (LVMI) as well as septal and posterior-wall thickness decreased significantly after 12.8 and 38.5 months (P < 0.001). After a mean of 38.5 months LVMI had decreased by 36.7% in group 1, 35.1% in group 2, 42.3% in group 3, 45% in group 4 and 39.6% in group 5. LVMI was within normal range (≤95 g/m2) in 81 of the 117 patients (69.2%) at the end of the treatment period. There was, however, no significant increase of the end-diastolic dimension of the left ventricle, but a significant increase of 'fractional shortening' as a measure of myocardial contractility.
引用
收藏
页码:603 / 609
页数:7
相关论文
共 56 条
[1]   CLINICAL-SIGNIFICANCE AND PROGNOSTIC IMPORTANCE OF LEFT-VENTRICULAR HYPERTROPHY IN NON-Q-WAVE ACUTE MYOCARDIAL-INFARCTION [J].
BODEN, WE ;
KLEIGER, RE ;
SCHECHTMAN, KB ;
CAPONE, RJ ;
SCHWARTZ, DJ ;
GIBSON, RS .
AMERICAN JOURNAL OF CARDIOLOGY, 1988, 62 (16) :1000-1004
[2]   VALUE OF ECHOCARDIOGRAPHIC MEASUREMENT OF LEFT-VENTRICULAR MASS IN PREDICTING CARDIOVASCULAR MORBID EVENTS IN HYPERTENSIVE MEN [J].
CASALE, PN ;
DEVEREUX, RB ;
MILNER, M ;
ZULLO, G ;
HARSHFIELD, GA ;
PICKERING, TG ;
LARAGH, JH .
ANNALS OF INTERNAL MEDICINE, 1986, 105 (02) :173-178
[3]  
CIFKOVA R, 1987, 3RD EUR M HYP MAIL
[4]  
COREA L, 1984, INT J CLIN PHARM TH, V22, P365
[5]   ECHOCARDIOGRAPHIC DETERMINATION OF LEFT-VENTRICULAR MASS IN MAN - ANATOMIC VALIDATION OF METHOD [J].
DEVEREUX, RB ;
REICHEK, N .
CIRCULATION, 1977, 55 (04) :613-618
[6]   LEFT-VENTRICULAR HYPERTROPHY IN PATIENTS WITH HYPERTENSION - IMPORTANCE OF BLOOD-PRESSURE RESPONSE TO REGULARLY RECURRING STRESS [J].
DEVEREUX, RB ;
PICKERING, TG ;
HARSHFIELD, GA ;
KLEINERT, HD ;
DENBY, L ;
CLARK, L ;
PREGIBON, D ;
JASON, M ;
KLEINER, B ;
BORER, JS ;
LARAGH, JH .
CIRCULATION, 1983, 68 (03) :470-476
[7]  
DIMITRIOU R, 1985, JAMA-J AM MED ASSOC, V4, P10
[8]   CARDIAC-MUSCLE MASS DURING VASODILATION THERAPY OF HYPERTENSION [J].
DRAYER, JIM ;
GARDIN, JM ;
WEBER, MA ;
ARONOW, WS .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1983, 33 (06) :727-732
[9]   CHANGES IN VENTRICULAR SEPTAL THICKNESS DURING DIURETIC THERAPY [J].
DRAYER, JIM ;
GARDIN, JM ;
WEBER, MA ;
ARONOW, WS .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1982, 32 (03) :283-288
[10]   PATHOPHYSIOLOGIC ASSESSMENT OF HYPERTENSIVE HEART-DISEASE WITH ECHOCARDIOGRAPHY [J].
DUNN, FG ;
CHANDRARATNA, P ;
DECARVALHO, JGR ;
BASTA, LL ;
FROHLICH, ED .
AMERICAN JOURNAL OF CARDIOLOGY, 1977, 39 (06) :789-795