THE CD19-CR-2-TAPA-1 COMPLEX, CD45 AND SIGNALING BY THE ANTIGEN RECEPTOR OF B-LYMPHOCYTES

被引：76
作者：
FEARON, DT [1 ]
机构：
[1] UNIV CAMBRIDGE,SCH CLIN MED,CAMBRIDGE,ENGLAND
来源：
CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 03期
关键词：
D O I：
10.1016/0952-7915(93)90051-S
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A paradigm describing the response of T lymphocytes to antigen holds that signals from antigen receptors must be modulated by non-antigen-specific, accessory membrane proteins for an appropriate cellular response to occur, such as differentiation, activation and tolerance. Recent studies suggest that this paradigm applies also to B lymphocytes. Signaling through membrane IgM in these cells requires CD45, a phosphotyrosine phosphatase, and is amplified by a complex containing CD19, complement receptor 2 (CD21), and TAPA-1, which recruits the intracellular enzyme, phosphatidylinositol 3-kinase.
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页码：341 / 348
页数：8
相关论文
共 96 条
[1]   ASSOCIATION OF CD2 AND T200 (CD45) IN MOUSE LYMPHOCYTE-T [J].
ALTEVOGT, P ;
SCHRECK, J ;
SCHRAVEN, B ;
MEUER, S ;
SCHIRRMACHER, V ;
MITSCH, A .
INTERNATIONAL IMMUNOLOGY, 1990, 2 (04) :353-360
[2]  
AMIOT M, 1990, J IMMUNOL, V145, P4322
[3]   THE HUMAN-LEUKOCYTE SURFACE-ANTIGEN CD53 IS A PROTEIN STRUCTURALLY SIMILAR TO THE CD37 AND MRC OX-44 ANTIGENS [J].
ANGELISOVA, P ;
VLCEK, C ;
STEFANOVA, I ;
LIPOLDOVA, M ;
HOREJSI, V .
IMMUNOGENETICS, 1990, 32 (04) :281-285
[4]   CD21 IS A LIGAND FOR CD23 AND REGULATES IGE PRODUCTION [J].
AUBRY, JP ;
POCHON, S ;
GRABER, P ;
JANSEN, KU ;
BONNEFOY, JY .
NATURE, 1992, 358 (6386) :505-507
[5]  
AZORSA DO, 1991, BLOOD, V78, P280
[6]   PHOSPHATIDYLINOSITOL 3'-KINASE IS ACTIVATED BY ASSOCIATION WITH IRS-1 DURING INSULIN STIMULATION [J].
BACKER, JM ;
MYERS, MG ;
SHOELSON, SE ;
CHIN, DJ ;
SUN, XJ ;
MIRALPEIX, M ;
HU, P ;
MARGOLIS, B ;
SKOLNIK, EY ;
SCHLESSINGER, J ;
WHITE, MF .
EMBO JOURNAL, 1992, 11 (09) :3469-3479
[7]   THE OX-44 MOLECULE COUPLES TO SIGNALING PATHWAYS AND IS ASSOCIATED WITH CD2 ON RAT LYMPHOCYTES-T AND A NATURAL-KILLER-CELL LINE [J].
BELL, GM ;
SEAMAN, WE ;
NIEMI, EC ;
IMBODEN, JB .
JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (02) :527-536
[8]   THE RAT LEUKOCYTE ANTIGEN MRC OX-44 IS A MEMBER OF A NEW FAMILY OF CELL-SURFACE PROTEINS WHICH APPEAR TO BE INVOLVED IN GROWTH-REGULATION [J].
BELLACOSA, A ;
LAZO, PA ;
BEAR, SE ;
TSICHLIS, PN .
MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (05) :2864-2872
[9]  
BOTTGER EC, 1985, J IMMUNOL, V135, P4100
[10]  
BOUCHEIX C, 1991, J BIOL CHEM, V266, P117
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