THE FORMATION OF 2,3-DIHYDROXY-2,3-DIHYDRO-AFLATOXIN-B1 BY THE METABOLISM OF AFLATOXIN-B1 BY LIVER-MICROSOMES ISOLATED FROM CERTAIN AVIAN AND MAMMALIAN-SPECIES AND THE POSSIBLE ROLE OF THIS METABOLITE IN THE ACUTE TOXICITY OF AFLATOXIN-B1

被引：79
|
作者：
NEAL, GE
JUDAH, DJ
STIRPE, F
PATTERSON, DSP
机构：
[1] MRC LABS, TOXICOL UNIT, WOODMANSTERNE RD, CARSHALTON SM5 4EF, SURREY, ENGLAND
[2] CENT VET LAB, WEYBRIDGE KT15 3NB, SURREY, ENGLAND
来源：
TOXICOLOGY AND APPLIED PHARMACOLOGY | 1981年 / 58卷 / 03期
关键词：
D O I：
10.1016/0041-008X(81)90095-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Separation of aflatoxin B2a and 2,3-dihydroxy-2,3-dihydro-aflatoxin B1 (AFB1-dhd) and the Tris complexes of these compounds by high-performance liquid chromatography is described. Examination of the metabolism of aflatoxin B1 by microsomes isolated from rat, mouse, guinea pig and chicken livers showed that the reported production of AFB2a was due to a misidentification of AFB1-dhd. Relative production of this metabolite by microsomes from the various species paralleled their in vivo susceptibilities to acute aflatoxin B1 poisoning. AFB1-dhd was a potent inhibitor of protein synthesis in an in vitro system and this may be a mechanism relevant to the acutely toxic action of aflatoxin B1.
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页码：431 / 437
页数：7
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