EXPRESSION OF ADHESION MOLECULES ICAM-1 AND LFA-3 IN COLORECTAL ADENOMAS AND CARCINOMAS

被引：0

作者：

DOUSSIS, IA ^{[1
]}

KAKLAMANIS, L ^{[1
]}

MORTENSEN, N ^{[1
]}

HARRIS, AL ^{[1
]}

GATTER, KC ^{[1
]}

机构：

[1] JOHN RADCLIFFE HOSP,NUFFIELD DEPT PATHOL,OXFORD OX3 9DU,ENGLAND

来源：

DIAGNOSTIC ONCOLOGY | 1992年 / 2卷 / 05期

关键词：

ADHESION MOLECULES; COLORECTAL CARCINOMA; IMMUNOHISTOCHEMISTRY;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor cells can escape immune recognition in vivo by at least three possible means: altered expression of HLA molecules, immunogenic peptides or accessory molecules involved in cell adhesion. The immunohistochemical expression of the adhesion molecules LFA-3 and ICAM-1 was examined in 15 colorectal adenomas and 56 carcinomas. None of the adenomas and only 1 of the carcinomas showed loss of LFA-3, while ICAM-1, which is not normally expressed in colonic epithelium, was detected de novo in 3 cases. These findings question the hypothesis that neoplastic alterations of LFA-3 and/or ICAM-1 expressed by tumor cells play a major role in the evasion of immune recognition by cytotoxic T lymphocytes.

引用

页码：283 / 288

页数：6