GLUCOCORTICOIDS, LIPOCORTINS AND THE IMMUNE-RESPONSE

被引：103
作者：
GOULDING, NJ [1 ]
GUYRE, PM [1 ]
机构：
[1] ST BARTHOLOMEWS HOSP,COLL MED,DEPT RHEUMATOL,LONDON EC1M 6BQ,ENGLAND
来源：
CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 01期
关键词：
D O I：
10.1016/0952-7915(93)90089-B
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Glucocorticoids are immunosuppressive and antiinflammatory agents that act through multiple mechanisms. This review highlights recent evidence that lipocortin-1, a member of the annexin family of calcium-binding proteins, can be induced by glucocorticoids, and may mediate some of the effects of glucocorticoids through putative lipocortin-1 receptors, which have been found on the surface of phagocytic cells. Recent advances in annexin biology have been drawn together to formulate a novel hypothesis for the regulation of inflammation,
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页码：108 / 113
页数：6
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