ASYMMETRIC CATALYSIS .77. NEW OPTICALLY-ACTIVE PYRAZOLE DERIVATIVES FOR ENANTIOSELECTIVE CATALYSIS

Starting from the amines 3 - 6 and the dipyrazolopyrazinedione 2, the optically active (pyrazolylmethyl)amines 11 - 14 have been synthesized. Furthermore, the preparation of the (+)-camphor-derived optically active pyrazole 17 is described. Pyrazoles 11 - 13 and 17 are introduced as chiral building blocks into the 2-(1-pyrazolyl)pyridines 30 - 33. The optically active compounds 23 - 25 are formed from 2-[3(5)-pyrazolyl]pyridine and 2,6-bis[3(5-)pyrazolyl]pyridine, respectively, and (+)-3-(bromomethyl)pinane. The pyrazole derivatives 27 - 29 contain (+)-(1-phenylethyl)hydrazine as the optically active component.