INTERLEUKIN-1 IS A MUCUS SECRETAGOGUE

被引：59

作者：

COHAN, VL

SCOTT, AL

DINARELLO, CA

PRENDERGAST, RA

机构：

[1] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT IMMUNOL & INFECT DIS,BALTIMORE,MD 21205

[2] TUFTS UNIV,DEPT MED,BOSTON,MA 02111

[3] NEW ENGLAND MED CTR HOSP,BOSTON,MA 02111

[4] JOHNS HOPKINS UNIV,SCH MED,WILMER OPHTHALMOL INST,BALTIMORE,MD 21205

来源：

CELLULAR IMMUNOLOGY | 1991年 / 136卷 / 02期

关键词：

D O I：

10.1016/0008-8749(91)90364-H

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Explant cultures of mouse duodenum were used to show that interleukin-1 (IL-1) causes release of mucus from epithelial goblet cells. Our experiments made use of a newly described enzyme-linked lectin assay (ELLA) which employs enzyme-conjugated soybean agglutinin to detect mucus glycoproteins secreted from explant cultures of mouse duodenum. Supernatants from cultures of lipopolysaccharide-stimulated peritoneal macrophages as well as partially purified rabbit alveolar macrophage-derived IL-1 and human rIL-1β all induced mucus release in a rapid and dose-dependent fashion. This observation may be important for investigating a link between the immune response and mucus hypersecretion from inflamed intestinal mucosa. © 1991.

引用

页码：425 / 434

页数：10

共 22 条

[1] MULTIPLE BIOLOGICAL-ACTIVITIES OF HUMAN RECOMBINANT INTERLEUKIN-1 [J].