INTRAMOLECULAR CYCLIZATION REACTIONS BY USE OF ORGANOLITHIUM COMPOUNDS

Any reaction that results in ring formation can be of considerable potential use in organic synthesis. Nucleophilic center introduced through various kinds of lithiation undergoes intramolecular bond-forming reaction with the internal electrophilic center. Furthermore, the lithiated intermediate generated in this reaction reacts with various electrophiles to afford the products which have the substituents originated from electrophiles. This paper reviews the intramolecular cyclization reaction initiated through organolithium compounds.