HYDROGELS FOR SITE-SPECIFIC ORAL-DRUG DELIVERY - SYNTHESIS AND CHARACTERIZATION

被引：144
|
作者：
BRONDSTED, H
KOPECEK, J
机构：
[1] UNIV UTAH,DEPT PHARMACEUT,SALT LAKE CITY,UT 84112
[2] UNIV UTAH,CTR CONTROLLED CHEM DELIVERY,SALT LAKE CITY,UT 84112
来源：
BIOMATERIALS | 1991年 / 12卷 / 06期
关键词：
SITE-SPECIFIC DRUG DELIVERY; HYDROGELS; N-SUBSTITUTED (METH)ACRYLAMIDES; AZOAROMATIC CROSS-LINKS; PH-DEPENDENT SWELLING;
D O I：
10.1016/0142-9612(91)90056-G
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Novel types of hydrogels based on hydrophilic N-substituted (meth)acrylamides, N-tert-butylacrylamide and acrylic acid cross-linked with 4,4'-di(methacryloylamino)azobenzene were synthesized. The gels were characterized by the equilibrium degree of swelling as a function of pH, modulus of elasticity in compression at pH 2 and 7.4 and permeability of insulin at pH 2 and 7.4. It was found that the structure of the polymer backbone influenced the pH-dependent swelling. In all cases, the degree of swelling was lower at pH 2 than at 7.4. As the degree of swelling decreased, the modulus of elasticity was found to increase and the permeability of insulin decreased. These gels are enzymatically degradable by microbial azoreductases present in the colon and have a potential use in site-specific drug delivery to the colon.
引用
收藏
页码：584 / 592
页数：9
相关论文
共 50 条
  • [1] Hydrogels for colon-specific oral drug delivery: Synthesis and characterization
    Bajpai, SK
    Sonkusley, SJ
    JOURNAL OF MACROMOLECULAR SCIENCE-PURE AND APPLIED CHEMISTRY, 2001, 38 (04): : 365 - 381
  • [2] Hydrogels for oral drug delivery of peptides: synthesis and characterization
    Bajpai, SK
    JOURNAL OF APPLIED POLYMER SCIENCE, 2002, 83 (08) : 1717 - 1729
  • [3] Towards soft robotic devices for site-specific drug delivery
    Alici, Gursel
    EXPERT REVIEW OF MEDICAL DEVICES, 2015, 12 (06) : 703 - 715
  • [4] Dextran hydrogels for colon-specific drug delivery .2. Synthesis and characterization
    Brondsted, H
    Hovgaard, L
    Simonsen, L
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 1995, 41 (06) : 341 - 345
  • [5] Hydrogels Based Drug Delivery Synthesis, Characterization and Administration
    Onaciu, Anca
    Munteanu, Raluca Andrada
    Moldovan, Alin Iulian
    Moldovan, Cristian Silviu
    Berindan-Neagoe, Ioana
    PHARMACEUTICS, 2019, 11 (09)
  • [6] The development of site-specific drug delivery nanocarriers based on receptor mediation
    Wang, Xueqing
    Li, Suxin
    Shi, Yujie
    Chuan, Xingxing
    Li, Ji
    Zhong, Ting
    Zhang, Hua
    Dai, Wenbing
    He, Bing
    Zhang, Qiang
    JOURNAL OF CONTROLLED RELEASE, 2014, 193 : 139 - 153
  • [7] Preparation and characterization of freeze-dried chitosan-poly(ethylene oxide) hydrogels for site-specific antibiotic delivery in the stomach
    Patel, VR
    Amiji, MM
    PHARMACEUTICAL RESEARCH, 1996, 13 (04) : 588 - 593
  • [8] SITE-SPECIFIC DRUG-DELIVERY TO PILOSEBACEOUS STRUCTURES USING POLYMERIC MICROSPHERES
    ROLLAND, A
    WAGNER, N
    CHATELUS, A
    SHROOT, B
    SCHAEFER, H
    PHARMACEUTICAL RESEARCH, 1993, 10 (12) : 1738 - 1744
  • [9] Polymeric endoluminal gel paving: Hydrogel systems for local barrier creation and site-specific drug delivery
    Slepian, MJ
    Hubbell, JA
    ADVANCED DRUG DELIVERY REVIEWS, 1997, 24 (01) : 11 - 30
  • [10] Direct compressible polymethacrylic acid-starch compositions for site-specific drug delivery
    Clausen, AE
    Bernkop-Schnürch, A
    JOURNAL OF CONTROLLED RELEASE, 2001, 75 (1-2) : 93 - 102
12345