CISPLATIN AND TENIPOSIDE CHEMOTHERAPY FOR ADVANCED NON-SMALL-CELL LUNG-CANCER

被引：3

作者：

IBERTI, V ^{[1
]}

DONADIO, M ^{[1
]}

GIACCONE, G ^{[1
]}

机构：

[1] OSPED SAN GIOVANNI ANTICA SEDE, DIV MED ONCOL, TURIN, ITALY

来源：

EUROPEAN JOURNAL OF CANCER | 1991年 / 27卷 / 09期

关键词：

D O I：

10.1016/0277-5379(91)90302-T

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

30 patients with advanced non-small cell lung cancer were treated with cisplatin 80 mg/m2, day 1, and teniposide 100 or 120 mg/m2, days 1, 3 and 5, every 3 weeks. Myelotoxicity, nausea and vomiting and alopecia were the main side-effects. 8 patients of 26 evaluable had partial responses (31%): 6 had received 120 mg/m2 teniposide and 2 had received 100 mg/m2 teniposide. Overall median survival time was 251 days. Myelotoxicity was significantly lower in patients who received 100 mg/m2 teniposide. Although the number of patients is small and they were not randomly assigned to the two different teniposide doses, it appears that higher dose of teniposide determined a greater degree of myelotoxicity, and also a higher response rate.

引用

页码：1104 / 1106

页数：3