CONFORMATION AND MOLECULAR-BIOLOGY OF POLYPEPTIDE HORMONES .1. INSULIN, INSULIN-LIKE GROWN FACTOR AND RELAXIN

被引：21

作者：

BLUNDELL, T

机构：

[1] Tom Blundell is at the Laboratory of Molecular Biology, Department of Crystallography, Birbeck College, WCIE 7HX, Malet Street, London

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1979年 / 4卷 / 03期

关键词：

D O I：

10.1016/0968-0004(79)90261-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Insulin exists in dilute aqueous solutions as, a relatively stable globular structure, the maintenance of which appears to be important in receptor recognition. A similar conformation is probably adopted by the homologous insulin-like growth factor, which can exhibit insulin-like activity but which does not bind to anti-insulin antibodies. Relaxin, a hormone from the corpus luteum involved in relaxation of the pubis symphysis prior to parturition, may also have an insulin-like tertiary structure but has no insulin-like activity. © 1979.

引用

页码：51 / 54

页数：4

共 30 条

[1] RELAXIN HAS CONFORMATIONAL HOMOLOGY WITH INSULIN [J].

BEDARKAR, S ;

TURNELL, WG ;

BLUNDELL, TL ;

SCHWABE, C .

NATURE, 1977, 270 (5636) :449-451

[2] STRUCTURE OF INSULIN IN 4-ZINC INSULIN [J].

BENTLEY, G ;

DODSON, E ;

DODSON, G ;

HODGKIN, D ;

MERCOLA, D .

NATURE, 1976, 261 (5556) :166-168

[3]

BLUNDELL T, 1972, ADV PROTEIN CHEM, V26, P280

[4] ATOMIC POSITIONS IN RHOMBOHEDRAL 2-ZINC INSULIN CRYSTALS [J].

BLUNDELL, TL ;

CUTFIELD, JF ;

CUTFIELD, SM ;

DODSON, EJ ;

DODSON, GG ;

HODGKIN, DC ;

MERCOLA, DA ;

VIJAYAN, M .

NATURE, 1971, 231 (5304) :506-&

[5] IS EVOLUTION OF INSULIN DARWINIAN OR DUE TO SELECTIVELY NEUTRAL MUTATION [J].

BLUNDELL, TL ;

WOOD, SP .

NATURE, 1975, 257 (5523) :197-203

[6] INSULIN-LIKE GROWTH-FACTOR - MODEL FOR TERTIARY STRUCTURE ACCOUNTING FOR IMMUNOREACTIVITY AND RECEPTOR-BINDING [J].

BLUNDELL, TL ;

BEDARKAR, S ;

RINDERKNECHT, E ;

HUMBEL, RE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (01) :180-184

[7] LOW RESOLUTION CRYSTAL-STRUCTURE OF HAGFISH INSULIN [J].

CUTFIELD, JF ;

CUTFIELD, SM ;

DODSON, EJ ;

DODSON, GG ;

SABESAN, MN .

JOURNAL OF MOLECULAR BIOLOGY, 1974, 87 (01) :23-30

[8]

DEMEYTZ P, 1976, J BIOL CHEM, V251, P1867

[9]

FREYCHET P, 1975, DIABETOLOGIA, V10, P1

[10] ANTIBODY-SUPPRESSIBLE AND NONSUPPRESSIBLE INSULIN-LIKE ACTIVITIES IN HUMAN SERUM AND THEIR PHYSIOLOGIC SIGNIFICANCE - AN INSULIN ASSAY WITH ADIPOSE TISSUE OF INCREASED PRECISION AND SPECIFICITY [J].

FROESCH, ER ;

LABHART, A ;

RAMSEIER, EB ;

BURGI, H ;

BALLY, P .

JOURNAL OF CLINICAL INVESTIGATION, 1963, 42 (11) :1816-&

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