SIMPLE SYNTHESIS OF A C-2 SYMMETRICAL VICINAL DIAMINE - HIGHLY DIASTEREOSELECTIVE GRIGNARD ADDITION TO A CHIRAL BIS-IMINE

被引：95

作者：

BAMBRIDGE, K ^{[1
]}

BEGLEY, MJ ^{[1
]}

SIMPKINS, NS ^{[1
]}

机构：

[1] UNIV NOTTINGHAM,DEPT CHEM,NOTTINGHAM NG7 2RD,ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(00)76916-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of the enantiomerically pure bis-imine derived from glyoxal and (R)-alpha-methylbenzylamine with PhMgCl in diethylether is highly diastereoselective, resulting in the selective formation of the C-2 symmetric vicinal diamine 7.

引用

页码：3391 / 3394

页数：4

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