SIMPLE SYNTHESIS OF A C-2 SYMMETRICAL VICINAL DIAMINE - HIGHLY DIASTEREOSELECTIVE GRIGNARD ADDITION TO A CHIRAL BIS-IMINE

被引：95
作者：
BAMBRIDGE, K [1 ]
BEGLEY, MJ [1 ]
SIMPKINS, NS [1 ]
机构：
[1] UNIV NOTTINGHAM,DEPT CHEM,NOTTINGHAM NG7 2RD,ENGLAND
来源：
TETRAHEDRON LETTERS | 1994年 / 35卷 / 20期
关键词：
D O I：
10.1016/S0040-4039(00)76916-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of the enantiomerically pure bis-imine derived from glyoxal and (R)-alpha-methylbenzylamine with PhMgCl in diethylether is highly diastereoselective, resulting in the selective formation of the C-2 symmetric vicinal diamine 7.
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页码：3391 / 3394
页数：4
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