FIBROBLAST GROWTH-FACTOR INDUCES PRIMITIVE STREAK FORMATION IN RABBIT PREIMPLANTATION EMBRYOS INVITRO

被引:24
作者
DEANGELIS, MH
KIRCHNER, C
机构
[1] Fachbereich Biologie, Universität Marburg, Marburg, W-3550
来源
ANATOMY AND EMBRYOLOGY | 1993年 / 187卷 / 03期
关键词
FIBROBLAST GROWTH FACTOR; MESODERM-INDUCING FACTOR; BLASTOCYST; INVITRO CULTURE; RABBIT;
D O I
10.1007/BF00195764
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Culturing of rabbit pre-implantation embryos was performed in Ham's F10 medium supplemented with polyvinylpyrrolidone. Under these culture conditions, day 6 post coitum blastocysts increased their diameter within 24 h to 80% of that of day 7 blastocysts grown in vivo. Despite this substained growth, the embryonic disc remained undifferentiated with clear signs of degeneration after 24 h of culture. Basic fibroblast growth factor (bFGF) was able to overcome this developmental block. After 12 h of culture, day 6 blastocysts showed pear-shaped embryonic discs, and after 24 h, the primitive streak with Hensen's node was visible. The bFGF had no comparable effects on day 5 and day 7 blastocysts. The embryonic discs of day 5 blastocysts degenerated, even in the presence of bFGF, whereas day 7 blastocysts were able to form their primitive streak, also in the absence of bFGF. TGFbeta1 did not promote embryonic development in vitro. The data indicate that the onset of mesoderm formation in the rabbit is controlled by a growth factor of the FGF-family.
引用
收藏
页码:269 / 273
页数:5
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