INDUCTION OF KROX-20 EXPRESSION AFTER FOCAL CEREBRAL-ISCHEMIA

被引：26

作者：

AN, G ^{[1
]}

LIN, TN ^{[1
]}

LIU, JS ^{[1
]}

HSU, CY ^{[1
]}

机构：

[1] BAYLOR COLL MED,DIV RESTORAT NEUROL,HOUSTON,TX 77030

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 188卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)91345-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Krox-20 is one of the transcription factors of "zinc finger" family. The expression of Krox-20 was investigated in a rat focal cerebral ischemia model by Northern blot analysis and in situ hybridization. Northern blot analysis showed that ischemia for 30 min which caused little cortical infarction induced a 29-fold increase in Krox-20 mRNA signal exclusively in the ischemic cortex. Ischemia for 90 min which led to large cortical infarction induced Krox-20 mRNA not only in the ischemic cortex but also in the ipsilateral hippocampus. The induction of Krox-20 mRNA was rapid, transient and appeared to be controlled at the transcriptional level, as indicated by nuclear run-on assays. The regional induction of Krox-20 mRNA was further confirmed by in situ hybridization. These results Suggest that the expression of transcription factor genes may play a role in the post-ischemic changes of the injured brain. © 1992.

引用

页码：1104 / 1110

页数：7

共 22 条

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AN G, 1992, UNPUB

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