PLATELET-ACTIVATING-FACTOR MAY MEDIATE DEXAMETHASONE-INDUCED GASTRIC DAMAGE IN THE RAT

被引：4
作者：
FILEP, J
HERMAN, F
BRAQUET, P
机构：
[1] SEMMELWEIS UNIV,SCH MED,DEPT PATHOPHYSIOL,H-1445 BUDAPEST,HUNGARY
[2] SEMMELWEIS UNIV,SCH MED,DEPT PHARMACODYNAM,H-1445 BUDAPEST,HUNGARY
[3] INST HENRI BEAUFOUR,F-92350 LE PLESSIS ROBINS,FRANCE
来源：
LIPIDS | 1991年 / 26卷 / 12期
关键词：
D O I：
10.1007/BF02536566
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The possible role of platelet-activating factor (PAF) in dexamethasone-induced gastric mucosal damage was studied in rats. PAF was measured by a platelet aggregation assay. The identity of the PAF-like product recovered from gastric tissues was ascertained by thin-layer chromatography and high-pressure liquid chromatography. Low levels of PAF were detected in the normal rat stomach, while in dexamethasone-treated animals PAF levels were significantly higher. Pretreatment of the animals with BN 52021, a specific PAF receptor antagonist, significantly attenuated dexamethasone-induced mucosal injury. These findings suggest that PAF may be a mediator of mucosal damage induced by gluco corticoids.
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收藏
页码：1356 / 1358
页数：3
相关论文
共 23 条
[1]   ANTIHYPERTENSIVE ACTIVITY OF AN ALKYL ETHER ANALOG OF PHOSPHATIDYLCHOLINE [J].
BLANK, ML ;
SNYDER, F ;
BYERS, LW ;
BROOKS, B ;
MUIRHEAD, EE .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1979, 90 (04) :1194-1200
[2]  
BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
[3]  
BRAQUET P, 1987, PHARMACOL REV, V39, P97
[4]   EFFECTS OF THE SPECIFIC PLATELET-ACTIVATING FACTOR ANTAGONISTS, BN-52021 AND BN-52063, ON VARIOUS EXPERIMENTAL GASTROINTESTINAL ULCERATIONS [J].
BRAQUET, P ;
ETIENNE, A ;
MENCIAHUERTA, JM ;
CLOSTRE, F .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 150 (03) :269-276
[5]  
Braquet P., 1985, BLOOD VESSELS, V16, P559
[6]  
EASTWOOD GL, 1984, MECHANISMS MUCOSAL P, P27
[7]   MECHANISMS CONTRIBUTING TO GASTRIC-MOTILITY CHANGES INDUCED BY PAF-ACETHER AND ENDOTOXIN IN RATS [J].
ESPLUGUES, JV ;
WHITTLE, BJR .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (02) :G275-G282
[8]   GASTRIC-MUCOSAL DAMAGE INDUCED BY LOCAL INTRA-ARTERIAL ADMINISTRATION OF PAF IN THE RAT [J].
ESPLUGUES, JV ;
WHITTLE, BJR .
BRITISH JOURNAL OF PHARMACOLOGY, 1988, 93 (01) :222-228
[9]   INCREASED LEVELS OF PLATELET-ACTIVATING FACTOR IN BLOOD FOLLOWING INTESTINAL ISCHEMIA IN THE DOG [J].
FILEP, J ;
HERMAN, F ;
BRAQUET, P ;
MOZES, T .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 158 (02) :353-359
[10]  
FOLDESFILEP E, 1987, BIOCHEM BIOPH RES CO, V148, P1412
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