COMPARISON OF T-CELL FUNCTIONAL-CHANGES DURING CHILDHOOD WITH THE ONTOGENY OF CDW29 AND CD45RA EXPRESSION ON CD4+ T-CELLS

被引:29
|
作者
PIRENNE, H
AUJARD, Y
ELJAAFARI, A
BOURILLON, A
OURY, JF
LEGAC, S
BLOT, P
STERKERS, G
机构
[1] HOP ROBERT DEBRE,SERV NEONATOL,F-75019 PARIS,FRANCE
[2] HOP ROBERT DEBRE,SERV PEDIAT GEN,F-75019 PARIS,FRANCE
[3] HOP ROBERT DEBRE,SERV GYNECOL OBSTET,F-75019 PARIS,FRANCE
关键词
D O I
10.1203/00006450-199207000-00016
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The ontogeny of the peripheral blood mononuclear cells' responsiveness to various activators during childhood was studied and compared to the expression of CDw29 and CD45RA molecules at the surface of CD4+ T cells. The results show that newborn peripheral blood mononuclear cells are characterized by a responsiveness to mitogens that is higher than that observed in adults, at least shortly after stimulation. This contrasts with a clear decreased response to CD2 and CD3 MAb at any time after stimulation. These functional characteristics correlate with a low density of CDw29 antigen on virtually all CD4+ T cells and a high density of CD45RA antigen on most CD4+ T cells at birth. These patterns of reactivity and phenotype are similar to those found among naive adult T cells. When ageing, the response to mitogens becomes rapidly similar to the adult's values, whereas the responses to CD2 or CD3 MAb are more gradually acquired. This slow rate of functional changes grossly parallels the increase of CDw29+ CD4+ and the decrease of CD45RA+ CD4+ T cell subsets. These changes finally lead to the immunophenotypic and functional characteristics that are typical of adult memory T cells. These results suggest that iterative antigenic stimulations both induce memory T cells and create the conditions to improve the overall immune competence.
引用
收藏
页码:81 / 86
页数:6
相关论文
共 50 条
  • [41] ADULT T-CELL LEUKEMIA-CELLS ARE OF CD4+ CDW29+ T-CELL ORIGIN AND SECRETE A B-CELL DIFFERENTIATION FACTOR
    YAMADA, Y
    ICHIMARU, M
    SHIKU, H
    BRITISH JOURNAL OF HAEMATOLOGY, 1989, 72 (03) : 370 - 377
  • [42] THE COEXPRESSION OF CD45RA AND CD45RO ISOFORMS ON T-CELLS DURING THE S/G2/M STAGES OF CELL-CYCLE
    LASALLE, JM
    HAFLER, DA
    CELLULAR IMMUNOLOGY, 1991, 138 (01) : 197 - 206
  • [43] CD4+ CD25+ regulatory T-cells exhibit a higher T-cell receptor diversity than CD4+ CD25- conventional T-cells after allogeneic stem cell transplantation
    Fozza, C.
    Nadal, E.
    Longinotti, M.
    Dazzi, F.
    BONE MARROW TRANSPLANTATION, 2007, 39 : S46 - S46
  • [44] A POSITIVE ROLE OF CD4(+)CD45RA(+) T-CELLS IN THE DEVELOPMENT OF ALLERGEN-SPECIFIC IMMUNE-RESPONSES
    NASERT, S
    MILLNER, M
    ROHRBACH, A
    NIGGEMANN, B
    WAHN, U
    RENZ, H
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1995, 95 (01) : 334 - 334
  • [45] CD45 isoform phenotypes of human T cells:: CD4+CD45RA-RO+ memory T cells re-acquire CD45RA without losing CD45RO
    Arlettaz, L
    Barbey, C
    Dumont-Girard, F
    Helg, C
    Chapuis, B
    Roux, E
    Roosnek, E
    EUROPEAN JOURNAL OF IMMUNOLOGY, 1999, 29 (12) : 3987 - 3994
  • [46] T-CELL RESPONSES Brainstorm by CD4+ T cells
    Allan, Sarah
    NATURE REVIEWS IMMUNOLOGY, 2009, 9 (02) : 75 - 75
  • [47] Different Proliferative Potential and Migratory Characteristics of Human CD4+ Regulatory T Cells That Express either CD45RA or CD45R0
    Booth, Nicola J.
    McQuaid, Arthur J.
    Sobande, Toni
    Kissane, Steve
    Agius, Elaine
    Jackson, Sarah E.
    Salmon, Mike
    Falciani, Francesco
    Yong, Kwee
    Rustin, Malcolm H.
    Akbar, Arne N.
    Vukmanovic-Stejic, Milica
    JOURNAL OF IMMUNOLOGY, 2010, 184 (08): : 4317 - 4326
  • [48] Functional avidity directs T-cell fate in autoreactive CD4+ T cells
    Mallone, R
    Kochik, SA
    Reijonen, H
    Carson, B
    Ziegler, SF
    Kwok, WW
    Nepom, GT
    BLOOD, 2005, 106 (08) : 2798 - 2805
  • [49] FREQUENCY OF CD4+ HELPER INDUCER AND CD4+ SUPPRESSOR INDUCER T-CELLS IN CD4+ CUTANEOUS T-CELL LYMPHOMAS AND CERTAIN INFLAMMATORY SKIN DISEASES
    STERRY, W
    MIELKE, V
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1989, 92 (03) : 523 - 523
  • [50] FREQUENCY OF CD4+ HELPER INDUCER AND CD4+ SUPPRESSOR INDUCER T-CELLS IN CD4+ CUTANEOUS T-CELL LYMPHOMAS AND CERTAIN INFLAMMATORY SKIN DISEASES
    STERRY, W
    MIELKE, V
    CLINICAL RESEARCH, 1989, 37 (02): : A630 - A630