THE EFFECT OF A23187 ON GLUCOSE-PRODUCTION FROM METHYLGLYOXAL AND PYRUVATE IN ISOLATED MURINE HEPATOCYTES

被引：3

作者：

KALAPOS, MP ^{[1
]}

RIBA, P ^{[1
]}

GARZO, T ^{[1
]}

ANTONI, F ^{[1
]}

MANDL, J ^{[1
]}

机构：

[1] SEMMELWEIS UNIV MED,SCH MED,INST BIOCHEM 1,POB 260,H-1444 BUDAPEST,HUNGARY

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1992年 / 24卷 / 03期

关键词：

D O I：

10.1016/0020-711X(92)90032-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. A23187 increased the glucose production from methylglyoxal in isolated hepatocytes, and maximal stimulation was obtained at 10(-6) M. The effect of A23187 was dependent on the presence of Ca2+. 2. Glucose production from pyruvate (less than 1 mM) in isolated hepatocytes was stimulated by A23187 in the presence of 2.5 mM Ca2+ and was depressed at pyruvate concentrations above 1 mM. Both the virtual K(m) and the virtual V(max) of glucose production from pyruvate were decreased by A23187.

引用

页码：411 / 414

页数：4

共 19 条

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