ALKYL AND ARYL ISOTHIOCYANATES AS MASKED PRIMARY AMINES

被引：22
作者：
CHO, CG [1 ]
POSNER, GH [1 ]
机构：
[1] JOHNS HOPKINS UNIV,SCH ARTS & SCI,DEPT CHEM,BALTIMORE,MD 21218
来源：
TETRAHEDRON LETTERS | 1992年 / 33卷 / 25期
关键词：
D O I：
10.1016/S0040-4039(00)92512-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Primary and secondary (but not tertiary) alkyl as well as aryl isothiocyanates react rapidly with 4-methyl-1,2-benzenedithiol (1) in methanol at room temperature, releasing the corresponding amines in good yields. This mild and simple procedure for unmasking amines proceeds chemospecifically with isothiocyanates even in the presence of such normally electrophilic and reactive functionalities as carboxylate ester and N-alkylphthalimide.
引用
收藏
页码：3599 / 3602
页数：4
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