IDENTIFICATION OF SUPEROXIDE-DISMUTASE IN RAT-LIVER PEROXISOMES

被引：43
|
作者：
WANDERS, RJA [1 ]
DENIS, S [1 ]
机构：
[1] UNIV AMSTERDAM HOSP,DEPT PEDIAT,AMSTERDAM,NETHERLANDS
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1115卷 / 03期
关键词：
PEROXISOME; SUPEROXIDE DISMUTASE;
D O I：
10.1016/0304-4165(92)90063-Z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this paper we have investigated whether or not superoxide dismutase is localized in peroxisomes from rat liver. Using an improved method to prepare peroxisomes from clofibrate induced rat livers, we identified superoxide dismutase activity in peroxisomes. This activity was found to be predominantly of the copper-zinc type. The finding of superoxide dismutase activity in peroxisomes makes sense since peroxisomes also contain superoxide generating enzyme activities such as xanthine oxidase.
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页码：259 / 262
页数：4
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