A COMPARISON OF TRANS-RNA SPLICING IN TRYPANOSOMES AND NEMATODES

被引：25

作者：

DONELSON, JE ^{[1
]}

ZENG, W ^{[1
]}

机构：

[1] UNIV IOWA,HOWARD HUGHES MED INST,IOWA CITY,IA 52242

来源：

PARASITOLOGY TODAY | 1990年 / 6卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0169-4758(90)90177-6

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Many aspects of the biology of kinetoplastids are unique, so it is surprising that they share with nematodes an unusual post-transcriptional process called trans-splicing. During this process, a small conserved RNA sequence is added to the 5′ non-translated ends of transcribed RNAs of protein-encoding genes. Trypanosomes and nematodes are the only organisms to date in which these sequences have been described, and the biological significance of trans-splicing remains a mystery but may be of wider occurrence in invertebrates. In this review, John Donelson and Wenlin Zeng compare the process in nematodes and trypanosomes and speculate on its raison d'être. © 1990.

引用

页码：327 / 334

页数：8

共 61 条

[1] 5'-TERMINAL CAP STRUCTURE IN EUKARYOTIC MESSENGER RIBONUCLEIC-ACIDS [J].