Targeted therapy of colorectal cancer - state of the art

被引：0

作者：

Utracka-Hutka, Beata ^{[1
]}

机构：

[1] Ctr Onkol Marii Curie Sklodowskiej Oddzial Gliwic, Klin Onkol Klin, Ul Armii Krajowej 15, PL-44101 Gliwice, Poland

来源：

WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY | 2006年 / 10卷 / 03期

关键词：

words: Colorectal cancer; targeted therapy; epidermal growth factor receptor (EGFR); vascular endothelial growth factor (VEGF);

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The recent development of drugs that target the key components of biologic pathways rendered an improvement in survival in colorectal cancer patients. Two monoclonal antibodies in particular, targeting vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) - bevacizumab and cetuximab are clinically available. The expectations with low molecular weight tyrosine kinase inhibitors in the treatment of colorectal cancer have not been confirmed. This review focuses on the defining role of the novel targeted agents in colorectal cancer.

引用

页码：121 / 127

页数：7

共 35 条

[11] The hallmarks of cancer [J].

Hanahan, D ;

Weinberg, RA .

CELL, 2000, 100 (01) :57-70

[12]

Hecht J, 2004, P CHEM S 22 NEW YORK

[13]

HECHT J, 2004, 2004 AM SOC CLIN ONC

[14]

Hecht JR, 2005, P ANN MEET AM SOC CL, V23

[15]

Hochster HS, 2005, GASTR CANC S

[16] Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer [J].

Hurwitz, H ;

Fehrenbacher, L ;

Novotny, W ;

Cartwright, T ;

Hainsworth, J ;

Heim, W ;

Berlin, J ;

Baron, A ;

Griffing, S ;

Holmgren, E ;

Ferrara, N ;

Fyfe, G ;

Rogers, B ;

Ross, R ;

Kabbinavar, F .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (23) :2335-2342

[17] Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU) leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer [J].

Kabbinavar, F ;

Hurwitz, HI ;

Fehrenbacher, L ;

Meropol, NJ ;

Novotny, WF ;

Lieberman, G ;

Griffing, S ;

Bergsland, E .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (01) :60-65

[18]

Klagsbrun Michael, 1996, Cytokine and Growth Factor Reviews, V7, P259, DOI 10.1016/S1359-6101(96)00027-5

[19] Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients [J].

Lee, JC ;

Chow, NH ;

Wang, ST ;

Huang, SM .

EUROPEAN JOURNAL OF CANCER, 2000, 36 (06) :748-753

[20]

McMahon G, 2000, Oncologist, V5 Suppl 1, P3

← 1 2 3 4 →