EFFECTS OF FATIGUE ON FORCE-VELOCITY RELATION OF DIAPHRAGM - ENERGETIC IMPLICATIONS

被引:23
作者
COIRAULT, C
CHEMLA, D
PERYMAN, N
SUARD, I
LECARPENTIER, Y
机构
[1] ECOLE POLYTECH,INSERM 275,F-91120 PALAISEAU,FRANCE
[2] HOP BICETRE,UER PARIS 11,SERV PHYSIOL,LE KREMLIN BICETR,FRANCE
关键词
D O I
10.1164/ajrccm.151.1.7812541
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Characteristics of the force (P)-velocity (V) relationship were investigated before and after fatigue in isolated diaphragm muscle of two species: mouse (n = 12), in which diaphragm is composed almost exclusively of fast-twitch fatigue-resistant fiber type, and rat (n = 12), in which diaphragm contains both fatigue-sensitive and fatigue-resistant fiber types. Following fatigue protocol, the mechanical performance of both the contraction and relaxation phases were significantly depressed in the two species. Consequences of the fatigue procedure on P-V characteristics differed markedly according to the two species. In mouse diaphragm, fatigue trial did not change the G curvature of the P-V hyperbola, the maximum mechanical efficiency Eff(max), or the normalized peak power output M(2). Conversely, in rat diaphragm, fatigue resulted in higher G curvature (p < 0.001), higher Eff(max) (p < 0.001) and a lower M(2) (p < 0.001) compared with control values. This suggests that fatigue improved the economy of force generation in mixed rat diaphragm and not in mouse. This is consistent with an increased proportion of slow fatigue-resistant fibers caused by fatigue of fast fatigue-sensitive fibers in rat diaphragm.
引用
收藏
页码:123 / 128
页数:6
相关论文
共 35 条
[1]   INCREASED MYOTHERMAL ECONOMY OF ISOMETRIC FORCE GENERATION IN COMPENSATED CARDIAC-HYPERTROPHY INDUCED BY PULMONARY-ARTERY CONSTRICTION IN THE RABBIT - A CHARACTERIZATION OF HEAT LIBERATION IN NORMAL AND HYPERTROPHIED RIGHT VENTRICULAR PAPILLARY-MUSCLES [J].
ALPERT, NR ;
MULIERI, LA .
CIRCULATION RESEARCH, 1982, 50 (04) :491-500
[3]   FORCE RESERVE OF THE DIAPHRAGM IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY-DISEASE [J].
BELLEMARE, F ;
GRASSINO, A .
JOURNAL OF APPLIED PHYSIOLOGY, 1983, 55 (01) :8-15
[4]   BIOCHEMICAL CHARACTERISTICS OF MAMMALIAN DIAPHRAGMS [J].
BLANK, S ;
CHEN, V ;
IANUZZO, CD .
RESPIRATION PHYSIOLOGY, 1988, 74 (01) :115-125
[5]   ONSET OF MECHANICAL ACTIVATION OF MAMMALIAN HEART-MUSCLE IN CALCIUM-CONTAINING AND STRONTIUM-CONTAINING SOLUTIONS [J].
BRUTSAERT, DL ;
CLAES, VA .
CIRCULATION RESEARCH, 1974, 35 (03) :345-357
[6]   MAMMALIAN MOTOR UNITS - PHYSIOLOGICAL-HISTOCHEMICAL CORRELATION IN 3 TYPES IN CAT GASTROCNEMIUS [J].
BURKE, RE ;
LEVINE, DN ;
ZAJAC, FE ;
TSAIRIS, P ;
ENGEL, WK .
SCIENCE, 1971, 174 (4010) :709-&
[7]   EFFECTS OF PH ON CONTRACTION OF RABBIT FAST AND SLOW SKELETAL-MUSCLE FIBERS [J].
CHASE, PB ;
KUSHMERICK, MJ .
BIOPHYSICAL JOURNAL, 1988, 53 (06) :935-946
[8]  
CHEMLA D, 1992, J PHARMACOL EXP THER, V262, P516
[9]   MECHANICAL DETERMINANTS OF ISOTONIC RELAXATION IN ISOLATED DIAPHRAGM MUSCLE [J].
COIRAULT, C ;
CHEMLA, D ;
PERY, N ;
SUARD, I ;
LECARPENTIER, Y .
JOURNAL OF APPLIED PHYSIOLOGY, 1993, 75 (05) :2265-2272
[10]  
COOKE R, 1988, J PHYSIOL-LONDON, V95, P77