Vascularized biocompatible synthetic tracheal matrix based on ultrafibrous polymeric material

被引：0
作者：
Kiselevskiy, Mikhail Valentinovich [1 ]
Anisimova, Natalia Yuryevna [1 ]
Shepelev, Alexey Dmitrievich [2 ]
Davydov, Mikhail Ivanovich [3 ]
Chvalun, Sergey Nikolaevich [2 ]
Kornushenkov, Evgeny Aleksandrovich [1 ]
Golub, Lev Valer'evich [1 ]
Petkevich, Alisa Antonovna [1 ]
机构：
[1] NN Blokhin Russian Canc Res Ctr, Lab Cell Immun, Moscow, Russia
[2] Natl Res Ctr, Kurchatov Inst, Materials Sci & Crystallog Unit, Akad Kurchatova Pl 1, Moscow, Russia
[3] NN Blokhin Russian Canc Res Ctr, Dept Thoracicoabdominal Surg, Moscow, Russia
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND ALLIED SCIENCES | 2016年 / 5卷 / 03期
关键词：
Trachea; Matrix; Scaffold; Mesenchymal multipotent stromal cells; Dogs;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We aimed to prepare a biocompatible synthetic vascularized tracheal scaffold for substitution of natural tracheae with life-threatening lesions Six beagle-dogs were implanted with polymeric tracheal matrices, the grafting was heterotopic to the formed intramuscular pocket in the groin. The implants were colonized by recipients' multipotent mesenchymal stromal cells (MMSC) before grafting. Tracheal matrices was electrospun from nonwoven fabric by a unique experimental monocapillary device for electrospun. Tracheal scaffolds were extracted from the groins in a month after the implantation. The scaffolds were covered by connective tissue capsule intimately interconnected with their matrix and were highly vascularized. Implants based on the nonwoven tracheal scaffolds colonized with recipient's MSC seem to be one of the most promising ways for trachea prosthesis.
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页码：91 / 96
页数：6
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