2,2-DIFLUORO-5-HEXYNE-1,4-DIAMINE - A POTENT ENZYME-ACTIVATED INHIBITOR OF ORNITHINE DECARBOXYLASE

被引：11
作者：
KENDRICK, DA
DANZIN, C
KOLB, M
机构：
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1989年 / 32卷 / 01期
关键词：
D O I：
10.1021/jm00121a031
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：170 / 173
页数：4
相关论文
共 24 条
[1]   ANALOGS OF ORNITHINE AS INHIBITORS OF ORNITHINE DECARBOXYLASE - NEW DEDUCTIONS CONCERNING TOPOGRAPHY OF ENZYMES ACTIVE-SITE [J].
BEY, P ;
DANZIN, C ;
VANDORSSELAER, V ;
MAMONT, P ;
JUNG, M ;
TARDIF, C .
JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (01) :50-55
[2]   ALPHA-(FLUOROMETHYL)DEHYDROORNITHINE AND ALPHA-(FLUOROMETHYL)DEHYDROPUTRESCINE ANALOGS AS IRREVERSIBLE INHIBITORS OF ORNITHINE DECARBOXYLASE [J].
BEY, P ;
GERHART, F ;
VANDORSSELAER, V ;
DANZIN, C .
JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (11) :1551-1556
[3]   STEREOSPECIFIC SYNTHESIS OF (2R,5R)-HEPT-6-YNE-2,5-DIAMINE - A POTENT AND SELECTIVE ENZYME-ACTIVATED IRREVERSIBLE INHIBITOR OF ORNITHINE DECARBOXYLASE (ODC) [J].
CASARA, P ;
DANZIN, C ;
METCALF, B ;
JUNG, M .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1985, (11) :2201-2207
[4]   ALPHA-MONOFLUOROMETHYL AND ALPHA-DIFLUOROMETHYL PUTRESCINE AS ORNITHINE DECARBOXYLASE INHIBITORS - INVITRO AND INVIVO BIOCHEMICAL-PROPERTIES [J].
DANZIN, C ;
BEY, P ;
SCHIRLIN, D ;
CLAVERIE, N .
BIOCHEMICAL PHARMACOLOGY, 1982, 31 (23) :3871-3878
[5]   (2R,5R)-6-HEPTYNE-2,5-DIAMINE, AN EXTREMELY POTENT INHIBITOR OF MAMMALIAN ORNITHINE DECARBOXYLASE [J].
DANZIN, C ;
CASARA, P ;
CLAVERIE, N ;
METCALF, BW ;
JUNG, MJ .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 116 (01) :237-243
[6]   EFFECT OF ALPHA-DIFLUOROMETHYLORNITHINE, AN ENZYME-ACTIVATED IRREVERSIBLE INHIBITOR OF ORNITHINE DECARBOXYLASE, ON POLYAMINE LEVELS IN RAT TISSUES [J].
DANZIN, C ;
JUNG, MJ ;
GROVE, J ;
BEY, P .
LIFE SCIENCES, 1979, 24 (06) :519-524
[7]   EFFECTS OF THE ENANTIOMERS OF 5-HEXYNE-1,4-DIAMINE ON ODC, GAD AND GABA-T ACTIVITIES IN THE RAT [J].
DANZIN, C ;
CASARA, P ;
CLAVERIE, N ;
GROVE, J .
BIOCHEMICAL PHARMACOLOGY, 1983, 32 (05) :941-942
[8]   DECREASE OF POLYAMINE LEVELS IN RAT-TISSUES BY 5-HEXYNE-1,4-DIAMINE, AN ENZYME-ACTIVATED IRREVERSIBLE INHIBITOR OF ORNITHINE DECARBOXYLASE [J].
DANZIN, C ;
JUNG, MJ ;
METCALF, BW ;
GROVE, J ;
CASARA, P .
BIOCHEMICAL PHARMACOLOGY, 1979, 28 (05) :627-631
[9]  
DIXON M, 1979, ENZYMES, P350
[10]  
Fuller R.W., 1976, ACS SYM SER, V28, P77
123