BENZOIC-ACID INHIBITORS OF INFLUENZA-VIRUS NEURAMINIDASE

被引：15
|
作者：
LUO, M
JEDRZEJAS, MJ
SINGH, S
WHITE, CL
BROUILLETTE, WJ
AIR, GM
LAVER, WG
机构：
[1] UNIV ALABAMA,DEPT CHEM,BIRMINGHAM,AL 35294
[2] UNIV ALABAMA,DEPT BIOCHEM & MOLEC GENET,BIRMINGHAM,AL 35294
[3] AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,CANBERRA,ACT 2601,AUSTRALIA
来源：
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY | 1995年 / 51卷
关键词：
D O I：
10.1107/S0907444994011698
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A strategy was developed to design non-carbohydrate inhibitors of influenza virus neuraminidase. Using an iterative cycle of modeling, synthesis, biological testing and X-ray crystallography structure determination, a series of inhibitors based on benzoic acid were produced. The refined structures of three compounds complexed with neuraminidase are reported. The results demonstrate the success of this structure-based drug-design strategy.
引用
收藏
页码：504 / 510
页数：7
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