BENZOIC-ACID INHIBITORS OF INFLUENZA-VIRUS NEURAMINIDASE

被引：15

作者：

LUO, M

JEDRZEJAS, MJ

SINGH, S

WHITE, CL

BROUILLETTE, WJ

AIR, GM

LAVER, WG

机构：

[1] UNIV ALABAMA,DEPT CHEM,BIRMINGHAM,AL 35294

[2] UNIV ALABAMA,DEPT BIOCHEM & MOLEC GENET,BIRMINGHAM,AL 35294

[3] AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,CANBERRA,ACT 2601,AUSTRALIA

来源：

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY | 1995年 / 51卷

关键词：

D O I：

10.1107/S0907444994011698

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A strategy was developed to design non-carbohydrate inhibitors of influenza virus neuraminidase. Using an iterative cycle of modeling, synthesis, biological testing and X-ray crystallography structure determination, a series of inhibitors based on benzoic acid were produced. The refined structures of three compounds complexed with neuraminidase are reported. The results demonstrate the success of this structure-based drug-design strategy.

引用

页码：504 / 510

页数：7

共 21 条

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