A SPECIFIC SEQUENCE OF STIMULATION IS REQUIRED TO INDUCE SYNTHESIS OF THE ANTIMICROBIAL MOLECULE NITRIC-OXIDE BY MOUSE MACROPHAGES

被引：64
作者：
LORSBACH, RB
RUSSELL, SW
机构：
[1] UNIV KANSAS,MED CTR,CTR CANC,WILKINSON LAB,KANSAS CITY,KS 66160
[2] UNIV KANSAS,MED CTR,DEPT PATHOL,KANSAS CITY,KS 66160
[3] UNIV KANSAS,MED CTR,DEPT ONCOL,KANSAS CITY,KS 66160
[4] UNIV KANSAS,MED CTR,DEPT MICROBIOL MOLEC GENET & IMMUNOL,KANSAS CITY,KS 66160
来源：
INFECTION AND IMMUNITY | 1992年 / 60卷 / 05期
关键词：
D O I：
10.1128/IAI.60.5.2133-2135.1992
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Nitric oxide production by macrophages required either simultaneous or sequential exposure to gamma interferon and lipopolysaccharide; exposure to lipopolysaccharide followed by exposure to gamma interferon gave little response. The apparently evanescent nature of the lipopolysaccharide signal, necessitating persistent stimulation, could be essential to down-regulating nitric oxide production after bacteria are cleared in vivo.
引用
收藏
页码：2133 / 2135
页数：3
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