Photodynamic Therapy as an Innovative Treatment for Malignant Pleural Mesothelioma

被引：34

作者：

Friedberg, Joseph S. ^{[1
]}

机构：

[1] Univ Penn, Med Ctr Presbyterian, Dept Thorac Surg, Philadelphia, PA 19104 USA

来源：

SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY | 2009年 / 21卷 / 02期

关键词：

photosensitizer; light-based cancer treatment; intracavitary therapy; pleurectomy and decortication;

D O I：

10.1053/j.semtcvs.2009.07.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Photodynamic therapy (PDT) of the pleura is an experimental treatment aimed at eradicating residual microscopic disease after macroscopic complete resection of malignant pleural mesothelioma (MPM) by means of intracavitary administration. A light-based treatment, PDT consists of 3 components: a nontoxic photosensitizing compound, oxygen, and visible light. The treatment is FDA-approved for several oncological targets, but remains experimental for MPM. PDT can be combined with lung-sparing pleurectomy and decortication and does not preclude other treatments such as adjuvant chemotherapy and/or radiation therapy. Additionally, PDT appears to bolster an immunologic effect by rendering the cancer cells that have been destroyed by the light-activated photosensitizer more presentable to the immune system. Local control and survival rates have been sufficiently rewarding to merit ongoing development of this combination of surgical technique and PDT. © 2009 Elsevier Inc. All rights reserved.

引用

页码：177 / 187

页数：11

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