VINYLSILANE MEDIATED STEREOSELECTIVE TOTAL SYNTHESIS OF (+/-)-GYMNOMITROL

被引：50

作者：

HAN, YK ^{[1
]}

PAQUETTE, LA ^{[1
]}

机构：

[1] OHIO STATE UNIV,EVANS CHEM LABS,COLUMBUS,OH 43210

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 21期

关键词：

D O I：

10.1021/jo01335a032

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and stereoselective synthesis of (i)-gymnomitrol was achieved by tandem conjugate addition-methylation of a vinylsilane reagent to 1, 5-dimethyl-2-methylenebicyclo[3.3.0]octan-3-one, followed by epoxidation, hydrolysis, cyclization, and introduction of the exocyclic methylene carbon. © 1979, American Chemical Society. All rights reserved.

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页码：3731 / 3733

页数：3

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