Iodine Catalyzed Highly Efficient One Pot Three Component Synthesis of 4-arylidene-3-methylisoxazol-5 (4H) -one in Aqueous Medium

被引：12

作者：

Nakkalwar, Srinivas L. ^{[1
]}

Patwari, Shivaji B. ^{[1
]}

Patel, Mohasim M. ^{[2
]}

Jadhav, Vivekanand B. ^{[2
]}

机构：

[1] Lal Bahadur Shastri Coll, Dept Chem, Dharmabad 431809, MH, India

[2] Shri Muktanand Coll, Dept Chem, Gangapur 431109, MH, India

来源：

CURRENT GREEN CHEMISTRY | 2018年 / 5卷 / 02期

关键词：

Aromatic aldehydes containing an electron donating groups; hydroxylamine hydrochloride; ethyl acetoacetate; 4-arylidene-3-methylisoxazol-5(4H)-ones; iodine & water;

D O I：

10.2174/2213346105666180711151320

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient one-pot three-component reaction of ethyl acetoacetate with hydroxylamine hydrochloride and various aromatic aldehydes containing an electron donating group, was carried out. The current protocol gives diverse 4-arylidene-3-methylisoxazol-5 (4H) -ones providing good to excellent yield of products in an aqueous medium using iodine as a catalyst. This particular cyclocondensation reaction was performed in water, which is an environmentally benign universal solvent having unique properties being clean, efficient, inexpensive, and readily available.

引用

页码：121 / 126

页数：6

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