CLONAL ORIGINS OF LYMPHOPROLIFERATIVE DISEASE INDUCED BY EPSTEIN-BARR-VIRUS

被引：32
作者：
BROWN, NA
LIU, CR
GARCIA, CR
WANG, YF
GRIFFITH, A
SPARKES, RS
CALAME, KL
机构：
[1] UNIV CALIF LOS ANGELES, SCH MED, DEPT PEDIAT, LOS ANGELES, CA 90024 USA
[2] UNIV CALIF LOS ANGELES, SCH MED, DEPT MED, LOS ANGELES, CA 90024 USA
[3] UNIV CALIF LOS ANGELES, SCH MED, DEPT BIOL CHEM, LOS ANGELES, CA 90024 USA
来源：
JOURNAL OF VIROLOGY | 1986年 / 58卷 / 03期
关键词：
D O I：
10.1128/JVI.58.3.975-978.1986
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Analysis of immunoglobulin gene rearrangments in 16 B-cell lineages clonally propagated from two mononucleosis patients supported the notion that mononucleosis is a polyclonal B-lymphoproliferative disorder. Three of seven cell clones from a patient with a fatal B lymphoma revealed the same pattern of immunoglobulin gene rearrangement, indicating that this patient''s disease was oligoclonal. The three similar clones were propagated from two sites (blood and spleen), indicating that they represent a metastatic cell lineage which arose during the patient''s fatal B lymphoproliferation.
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页码：975 / 978
页数：4
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