THE INS AND OUTS OF RAF KINASES

被引：487
作者：
DAUM, G
EISENMANNTAPPE, I
FRIES, HW
TROPPMAIR, J
RAPP, UR
机构：
[1] G. Daum, I. Eisenmann-Tappe, H-W. Fries, J. Troppmair and U.R. Rapp are at the Institute of Medical Radiobiology and Cell Biology, University of Würzburg, Versbacher Strasse 5
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 11期
关键词：
D O I：
10.1016/0968-0004(94)90133-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Raf kinases are signal-integrating enzymes that have the ability to switch tyrosine kinase signalling to serine/threonine phosphorylation and connect growth factor receptors with transcription factors. The connection involves a cascade of protein kinases that is essential for cellular proliferation and differentiation of species ranging from worms to humans. This cascade also mediates transformation by most oncogenes.
引用
收藏
页码：474 / 480
页数：7
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