BIOSYNTHETIC CAPACITIES OF ACTINOMYCETES .4. ECHINOSERINE, A NEW MEMBER OF THE QUINOXALINE GROUP, PRODUCED BY STREPTOMYCES-TENDAE

被引：14

作者：

BLUM, S

FIEDLER, HP

GROTH, I

KEMPTER, C

STEPHAN, H

NICHOLSON, G

METZGER, JW

JUNG, G

机构：

[1] UNIV TUBINGEN, INST BIOL, D-72076 TUBINGEN, GERMANY

[2] HANS KNOLL INST NAT STOFF FORSCH, D-07745 JENA, GERMANY

[3] UNIV TUBINGEN, INST ORGAN CHEM, D-72076 TUBINGEN, GERMANY

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 07期

关键词：

D O I：

10.7164/antibiotics.48.619

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new member of the quinoxaline group antibiotics has been detected by HPLC-diode-array screening. The main compound produced by Streptomyces tendae strain Tu 4031 showed a high degree of similarity in the UV-visible spectral region with echinomycin and their structural similarity was confirmed by structure elucidation using electron tandem mass spectrometry and 2D nuclear magnetic resonance. The new compound, named echinoserine, is a non-cyclic form of echinomycin, but it is not a biosynthetic precursor. Echinoserine is less antibiotically active than echinomycin.

引用

页码：619 / 625

页数：7

共 23 条

[1] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR [J].