GREATLY INCREASED LUMINAL NITRIC-OXIDE IN ULCERATIVE-COLITIS

被引：238

作者：

LUNDBERG, JON ^{[1
]}

HELLSTROM, PM ^{[1
]}

LUNDBERG, JM ^{[1
]}

ALVING, K ^{[1
]}

机构：

[1] KAROLINSKA HOSP,DEPT MED,S-10401 STOCKHOLM,SWEDEN

来源：

LANCET | 1994年 / 344卷 / 8938期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0140-6736(94)90460-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A role for nitric oxide (NO) in ulcerative colitis has been suggested because mucosal NO synthase activity, measured by indirect assays, is increased in this disorder. We directly measured luminal NO in the colons of twelve controls and six patients with active ulcerative colitis. During colonoscopy, gas was aspirated from different parts of the colon and immediately analysed by a chemiluminescence technique. NO concentrations were more than 100 times higher in the patients than in the controls. Luminal NO is rapidly and easily measurable and may be used to monitor inflammatory bowel disease.

引用

页码：1673 / 1674

页数：2

共 10 条

[1]

ALVING K, 1993, EUR RESPIR J, V6, P1368

[2] NITRIC-OXIDE SYNTHASE ACTIVITY IN ULCERATIVE-COLITIS AND CROHNS-DISEASE [J].