MAKE IT OR BREAK IT - THE ROLE OF UBIQUITIN-DEPENDENT PROTEOLYSIS IN CELLULAR-REGULATION

被引：77
作者：
DESHAIES, RJ
机构：
[1] Division of Biology 156-29, California Institute of Technology, Pasadena
来源：
TRENDS IN CELL BIOLOGY | 1995年 / 5卷 / 11期
关键词：
D O I：
10.1016/S0962-8924(00)89102-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Effective regulation of the concentration of a protein in the cell requires rapid protein degradation. Until recently, it was widely believed that intracellular proteolysis was largely confined to the turnover of damaged, or of otherwise abnormal, proteins. Recently, however, the role of protein degradation in cellular regulation has gained centre stage, and ubiquitin/proteasome-dependent proteolysis has been shown to play a key role in processes as diverse as embryonic development, transcription and the cell cycle.
引用
收藏
页码：428 / 434
页数：7
相关论文
共 46 条
[1]   CLOSING THE CELL-CYCLE CIRCLE IN YEAST - G2 CYCLIN PROTEOLYSIS INITIATED AT MITOSIS PERSISTS UNTIL THE ACTIVATION OF G1 CYCLINS IN THE NEXT CYCLE [J].
AMON, A ;
IRNIGER, S ;
NASMYTH, K .
CELL, 1994, 77 (07) :1037-1050
[2]   CACTUS PROTEIN-DEGRADATION MEDIATES DROSOPHILA DORSAL-VENTRAL SIGNALING [J].
BELVIN, MP ;
JIN, YS ;
ANDERSON, KV .
GENES & DEVELOPMENT, 1995, 9 (07) :783-793
[3]   CENTRAL OF I-KAPPA-B-ALPHA PROTEOLYSIS BY SITE-SPECIFIC, SIGNAL-INDUCED PHOSPHORYLATION [J].
BROWN, K ;
GERSTBERGER, S ;
CARLSON, L ;
FRANZOSO, G ;
SIEBENLIST, U .
SCIENCE, 1995, 267 (5203) :1485-1488
[4]   CYCLIN-LIKE ACCUMULATION AND LOSS OF THE PUTATIVE KINETOCHORE MOTOR CENP-E RESULTS FROM COUPLING CONTINUOUS SYNTHESIS WITH SPECIFIC DEGRADATION AT THE END OF MITOSIS [J].
BROWN, KD ;
COULSON, RMR ;
YEN, TJ ;
CLEVELAND, DW .
JOURNAL OF CELL BIOLOGY, 1994, 125 (06) :1303-1312
[5]  
CIECHANOVER A, 1994, J BIOL CHEM, V269, P9582
[6]   UBIQUITINATION OF THE G(1) CYCLIN CLN2P BY A CDC34P-DEPENDENT PATHWAY [J].
DESHAIES, RJ ;
CHAU, V ;
KIRSCHNER, M .
EMBO JOURNAL, 1995, 14 (02) :303-312
[7]   P40(SDB25), A PUTATIVE CDK INHIBITOR, HAS A ROLE IN THE M/G(1) TRANSITION IN SACCHAROMYCES-CEREVISIAE [J].
DONOVAN, JD ;
TOYN, JH ;
JOHNSON, AL ;
JOHNSTON, LH .
GENES & DEVELOPMENT, 1994, 8 (14) :1640-1653
[8]   THERMOLABILITY OF UBIQUITIN-ACTIVATING ENZYME FROM THE MAMMALIAN-CELL CYCLE MUTANT TS85 [J].
FINLEY, D ;
CIECHANOVER, A ;
VARSHAVSKY, A .
CELL, 1984, 37 (01) :43-55
[9]  
GLOTZER M, 1991, NATURE, V349, P132, DOI 10.1038/349132a0
[10]   THE YEAST-CELL CYCLE GENE CDC34 ENCODES A UBIQUITIN-CONJUGATING ENZYME [J].
GOEBL, MG ;
YOCHEM, J ;
JENTSCH, S ;
MCGRATH, JP ;
VARSHAVSKY, A ;
BYERS, B .
SCIENCE, 1988, 241 (4871) :1331-1335
12345