[H-3] SAXITOXINOL METABOLISM AND ELIMINATION IN THE RAT

被引：22

作者：

HINES, HB

NASEEM, SM

WANNEMACHER, RW

机构：

[1] Pathophysiology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick

来源：

TOXICON | 1993年 / 31卷 / 07期

关键词：

D O I：

10.1016/0041-0101(93)90226-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tritiated saxitoxinol was used to obtain preliminary information on saxitoxin metabolism in the rat. Sublethal doses of tritiated saxitoxinol (18.9-muCi/kg; 3.8 mug/kg) were injected i.v. into each of six rats. Urine and fecal samples were collected up to 144 hr post-injection. Within 4 hr, 60% of injected radioactivity was excreted in urine. No radioactivity was found in feces. High performance liquid chromatography analyses of urine showed that saxitoxinol was not metabolized by the rats.

引用

页码：905 / 908

页数：4

共 50 条

[1] METABOLISM OF CAFFEINE H-3 IN RAT
KHANNA, KL
CORNISH, HH
RAO, HS
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1972, 22 (02) : 292 - &
[2] DISPOSITION AND METABOLISM OF [H-3]PSEUDOMORPHINE IN RAT
MISRA, AL
MULE, SJ
BIOCHEMICAL PHARMACOLOGY, 1972, 21 (01) : 103 - &
[3] METABOLISM AND EXCRETION OF H-3 DIGITOXIN IN RAT
RIETBROCK, N
VOHRINGER, HF
BIOCHEMICAL PHARMACOLOGY, 1974, 23 (18) : 2567 - 2575
[4] Toxicokinetics of [H-3]saxitoxinol in peripheral and central nervous system of rats
Naseem, SM
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1996, 141 (01) : 49 - 58
[5] PHYSIOLOGIC DISPOSITION AND METABOLISM OF H-3 COCAINE IN RAT
NAYAK, PK
MISRA, AL
MULE, SJ
FEDERATION PROCEEDINGS, 1974, 33 (03) : 527 - 527
[6] METABOLISM OF [H-3] LEUPEPTIN BY RAT-LIVER
DENNIS, PA
ARONSON, NN
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1985, 240 (02) : 768 - 776
[7] UPTAKE AND METABOLISM OF H-3 ADRENALINE AND H-3 NORADRENALINE BY ISOLATED HEPATOCYTES AND LIVER SLICES OF THE RAT
MARTEL, F
AZEVEDO, I
OSSWALD, W
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1993, 348 (05) : 450 - 457
[8] DISPOSITION, KINETICS AND METABOLISM OF [H-3] PHENCYCLIDINE (PCF) IN THE RAT
MISRA, AL
PONTANI, RB
BARTOLOMEO, JG
FEDERATION PROCEEDINGS, 1980, 39 (03) : 302 - 302
[9] REGIONAL DISTRIBUTION AND METABOLISM OF H-3 TYRAMINE IN RAT BRAIN
GOLDSTEIN, M
ANAGNOSTE, B
YAMAMOTO, A
FELCH, WC
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1970, 171 (02): : 196 - +
[10] PHARMACOKINETICS AND METABOLISM OF THE ANTIARRHYTHMIC AGENT [H-3] DIPRAFENONE IN THE RAT
BRUNNER, F
KOLMAYR, U
KUKOVETZ, WR
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 1989, 39-2 (11): : 1430 - 1435

← 1 2 3 4 5 →