ROLE OF TYPE-1 AND TYPE-2 T-HELPER CELLS IN ALLERGIC DISEASES

被引：70

作者：

KAPSENBERG, ML

JANSEN, HM

BOS, JD

WIERENGA, EA

机构：

[1] UNIV AMSTERDAM, ACAD MED CTR, DEPT PULMONOL, 1105 AZ AMSTERDAM, NETHERLANDS

[2] UNIV AMSTERDAM, ACAD MED CTR, DEPT DERMATOL, 1105 AZ AMSTERDAM, NETHERLANDS

来源：

CURRENT OPINION IN IMMUNOLOGY | 1992年 / 4卷 / 06期

关键词：

D O I：

10.1016/0952-7915(92)90063-K

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Various characteristics of atopic allergic disorders seem to be causally related with the activation of allergen-specific T helper lymphocytes with a type 2 cytokine secretion profile, including high levels of interleukin-4 and interleukin-5. These cytokines are responsible for the occurrence of elevated levels of serum allergen-specific IgE and eosinophilia and play an important role in local inflammatory reactions.

引用

页码：788 / 793

页数：6