DETERMINATION OF THE CEREBRAL DOPAMINE-D2-RECEPTOR DENSITY BY I-123 IBZM-SPECT IN PATIENTS WITH PARKINSONS-DISEASE

被引：13
作者：
HIERHOLZER, J
CORDES, M
SCHELOSKY, L
BARZEN, G
POEWE, W
HENKES, H
KESKE, U
HOROWSKI, R
FELIX, R
机构：
[1] FREE UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,NEUROL KLIN & POLIKLIN,W-1000 BERLIN 65,GERMANY
[2] UNIV HOMBURG SAAR,FAK MED,INST NEURORADIOL,HOMBURG,GERMANY
[3] SCHERING AG,BERLIN,GERMANY
来源：
FORTSCHRITTE AUF DEM GEBIETE DER RONTGENSTRAHLEN UND DER NEUEN BILDGEBENDEN VERFAHREN | 1992年 / 157卷 / 04期
关键词：
DOPAMINE-RECEPTORS; PARKINSONS DISEASE; BASAL GANGLIA; SPECT; I-123-IBZM;
D O I：
10.1055/s-2008-1033028
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
An alteration of the dopaminergic nigrostriatal system is believed to be the main pathogenetic factor of Parkinson's disease (PD). We report on our initial results on the determination of the post-synaptic dopamine-D2-receptor binding of I-123-IBZM in patients with PD. Drug-native patients showed a significantly higher IBZM binding in the basal ganglia as compared to patients on specific dopaminergic medication. Age, duration of the disease and the severity of the disease do not seem to influence the IBZM-receptor binding. We conclude that I-123-IBZM-SPECT is an extremely useful tool for the evaluation of the functional state of cerebral dopamine-D2-receptors.
引用
收藏
页码：390 / 398
页数：9
相关论文
共 34 条
  • [21] LANGSTON JW, 1989, J NEUROL NEUROSUR PS, P13
  • [22] RECEPTOR BASIS FOR DOPAMINERGIC SUPER-SENSITIVITY IN PARKINSONS-DISEASE
    LEE, T
    SEEMAN, P
    RAJPUT, A
    FARLEY, IJ
    HORNYKIEWICZ, O
    [J]. NATURE, 1978, 273 (5657) : 59 - 61
  • [23] ON-OFF EFFECTS IN PATIENTS WITH PARKINSONS-DISEASE ON CHRONIC LEVODOPA THERAPY
    MARSDEN, CD
    PARKES, JD
    [J]. LANCET, 1976, 1 (7954) : 292 - 296
  • [24] MARTILLA RJ, 1987, HDB PARKINSONS DISEA, V35
  • [25] MUTSCH WJ, 1986, BRIT JMED, V292, P534
  • [26] Parkinson J., 1817, ESSAY SHAKING PALSY
  • [27] POSITRON EMISSION TOMOGRAPHY DEMONSTRATES DOPAMINE-D2 RECEPTOR SUPERSENSITIVITY IN THE STRIATUM OF PATIENTS WITH EARLY PARKINSONS-DISEASE
    RINNE, UK
    LAIHINEN, A
    RINNE, JO
    NAGREN, K
    BERGMAN, J
    RUOTSALAINEN, U
    [J]. MOVEMENT DISORDERS, 1990, 5 (01) : 55 - 59
  • [28] SINGHANYOM W, 1988, BRAIN RES, V453, P363
  • [29] TASCH K, 1991, J IBZM NUCL MED, V30
  • [30] TEDROFF J, 1990, ACTA U UPSAL, P268
1234